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1z6i

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{{STRUCTURE_1z6i| PDB=1z6i | SCENE= }}
{{STRUCTURE_1z6i| PDB=1z6i | SCENE= }}
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'''Crystal structure of the ectodomain of Drosophila transmembrane receptor PGRP-LCa'''
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===Crystal structure of the ectodomain of Drosophila transmembrane receptor PGRP-LCa===
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==Overview==
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The peptidoglycan-recognition protein LCa (PGRP-LCa) is a transmembrane receptor required for activation of the Drosophila immune deficiency pathway by monomeric Gram-negative peptidoglycan. We have determined the crystal structure of the ectodomain of PGRP-LCa at 2.5-A resolution and found two unique helical insertions in the LCa ectodomain that disrupt an otherwise L-shaped peptidoglycan-docking groove present in all other known PGRP structures. The deficient binding of PGRP-LCa to monomeric peptidoglycan was confirmed by biochemical pull-down assays. Recognition of monomeric peptidoglycan involves both PGRP-LCa and -LCx. We showed that association of the LCa and LCx ectodomains in vitro depends on monomeric peptidoglycan. The presence of a defective peptidoglycan-docking groove, while preserving a unique role in mediating monomeric peptidoglycan induction of immune response, suggests that PGRP-LCa recognizes the exposed structural features of a monomeric muropeptide when the latter is bound to and presented by the ectodomain of PGRP-LCx. Such features include N-acetyl glucosamine and the anhydro bond in the glycan of the muropeptide, which have been demonstrated to be critical for immune stimulatory activity.
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(as it appears on PubMed at http://www.pubmed.gov), where 16006509 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16006509}}
==About this Structure==
==About this Structure==
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[[Category: 3/10 helix]]
[[Category: 3/10 helix]]
[[Category: Mixed beta-sheet]]
[[Category: Mixed beta-sheet]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:13:57 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:16:16 2008''

Revision as of 12:16, 29 July 2008

Image:1z6i.png

Template:STRUCTURE 1z6i

Crystal structure of the ectodomain of Drosophila transmembrane receptor PGRP-LCa

Template:ABSTRACT PUBMED 16006509

About this Structure

1Z6I is a Single protein structure of sequence from Drosophila melanogaster. Full crystallographic information is available from OCA.

Reference

Structure of the ectodomain of Drosophila peptidoglycan-recognition protein LCa suggests a molecular mechanism for pattern recognition., Chang CI, Ihara K, Chelliah Y, Mengin-Lecreulx D, Wakatsuki S, Deisenhofer J, Proc Natl Acad Sci U S A. 2005 Jul 19;102(29):10279-84. Epub 2005 Jul 8. PMID:16006509

Page seeded by OCA on Tue Jul 29 15:16:16 2008

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