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1z6o

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[[Image:1z6o.gif|left|200px]]
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{{Seed}}
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[[Image:1z6o.png|left|200px]]
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{{STRUCTURE_1z6o| PDB=1z6o | SCENE= }}
{{STRUCTURE_1z6o| PDB=1z6o | SCENE= }}
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'''Crystal Structure of Trichoplusia ni secreted ferritin'''
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===Crystal Structure of Trichoplusia ni secreted ferritin===
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==Overview==
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Ferritins are iron storage proteins made of 24 subunits forming a hollow spherical shell. Vertebrate ferritins contain varying ratios of heavy (H) and light (L) chains; however, known ferritin structures include only one type of chain and have octahedral symmetry. Here, we report the 1.9A structure of a secreted insect ferritin from Trichoplusia ni, which reveals equal numbers of H and L chains arranged with tetrahedral symmetry. The H/L-chain interface includes complementary features responsible for ordered assembly of the subunits. The H chain contains a ferroxidase active site resembling that of vertebrate H chains with an endogenous, bound iron atom. The L chain lacks the residues that form a putative iron core nucleation site in vertebrate L chains. Instead, a possible nucleation site is observed at the L chain 3-fold pore. The structure also reveals inter- and intrasubunit disulfide bonds, mostly in the extended N-terminal regions unique to insect ferritins. The symmetrical arrangement of H and L chains and the disulfide crosslinks reflect adaptations of insect ferritin to its role as a secreted protein.
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The line below this paragraph, {{ABSTRACT_PUBMED_15896348}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15896348 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15896348}}
==About this Structure==
==About this Structure==
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[[Category: Jr., A P.West.]]
[[Category: Jr., A P.West.]]
[[Category: Metal binding protein,iron storage]]
[[Category: Metal binding protein,iron storage]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:14:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 11:24:42 2008''

Revision as of 08:24, 29 July 2008

Image:1z6o.png

Template:STRUCTURE 1z6o

Crystal Structure of Trichoplusia ni secreted ferritin

Template:ABSTRACT PUBMED 15896348

About this Structure

1Z6O is a Protein complex structure of sequences from Trichoplusia ni. Full crystallographic information is available from OCA.

Reference

Crystal structure of a secreted insect ferritin reveals a symmetrical arrangement of heavy and light chains., Hamburger AE, West AP Jr, Hamburger ZA, Hamburger P, Bjorkman PJ, J Mol Biol. 2005 Jun 10;349(3):558-69. Epub 2005 Apr 12. PMID:15896348

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