1z6t

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{{STRUCTURE_1z6t| PDB=1z6t | SCENE= }}
{{STRUCTURE_1z6t| PDB=1z6t | SCENE= }}
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'''Structure of the apoptotic protease-activating factor 1 bound to ADP'''
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===Structure of the apoptotic protease-activating factor 1 bound to ADP===
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==Overview==
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Apoptosis is executed by caspases, which undergo proteolytic activation in response to cell death stimuli. The apoptotic protease-activating factor 1 (Apaf-1) controls caspase activation downstream of mitochondria. During apoptosis, Apaf-1 binds to cytochrome c and in the presence of ATP/dATP forms an apoptosome, leading to the recruitment and activation of the initiator caspase, caspase-9 (ref. 2). The mechanisms underlying Apaf-1 function are largely unknown. Here we report the 2.2-A crystal structure of an ADP-bound, WD40-deleted Apaf-1, which reveals the molecular mechanism by which Apaf-1 exists in an inactive state before ATP binding. The amino-terminal caspase recruitment domain packs against a three-layered alpha/beta fold, a short helical motif and a winged-helix domain, resulting in the burial of the caspase-9-binding interface. The deeply buried ADP molecule serves as an organizing centre to strengthen interactions between these four adjoining domains, thus locking Apaf-1 in an inactive conformation. Apaf-1 binds to and hydrolyses ATP/dATP and their analogues. The binding and hydrolysis of nucleotides seem to drive conformational changes that are essential for the formation of the apoptosome and the activation of caspase-9.
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The line below this paragraph, {{ABSTRACT_PUBMED_15829969}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15829969 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15829969}}
==About this Structure==
==About this Structure==
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[[Category: Caspase activation]]
[[Category: Caspase activation]]
[[Category: Nucleotide binding]]
[[Category: Nucleotide binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:14:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:26:51 2008''

Revision as of 16:26, 27 July 2008

Image:1z6t.png

Template:STRUCTURE 1z6t

Structure of the apoptotic protease-activating factor 1 bound to ADP

Template:ABSTRACT PUBMED 15829969

About this Structure

1Z6T is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structure of the apoptotic protease-activating factor 1 bound to ADP., Riedl SJ, Li W, Chao Y, Schwarzenbacher R, Shi Y, Nature. 2005 Apr 14;434(7035):926-33. PMID:15829969

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