1z7z

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{{Seed}}
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{{STRUCTURE_1z7z| PDB=1z7z | SCENE= }}
{{STRUCTURE_1z7z| PDB=1z7z | SCENE= }}
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'''Cryo-em structure of human coxsackievirus A21 complexed with five domain icam-1kilifi'''
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===Cryo-em structure of human coxsackievirus A21 complexed with five domain icam-1kilifi===
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==Overview==
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CVA21 and polioviruses both belong to the Enterovirus genus in the family of Picornaviridae, whereas rhinoviruses form a distinct picornavirus genus. Nevertheless, CVA21 and the major group of human rhinoviruses recognize intercellular adhesion molecule-1 (ICAM-1) as their cellular receptor, whereas polioviruses use poliovirus receptor. The crystal structure of CVA21 has been determined to 3.2 A resolution. Its structure has greater similarity to poliovirus structures than to other known picornavirus structures. Cryo-electron microscopy (cryo-EM) was used to determine an 8.0 A resolution structure of CVA21 complexed with an ICAM-1 variant, ICAM-1(Kilifi). The cryo-EM map was fitted with the crystal structures of ICAM-1 and CVA21. Significant differences in the structure of CVA21 with respect to the poliovirus structures account for the inability of ICAM-1 to bind polioviruses. The interface between CVA21 and ICAM-1 has shape and electrostatic complementarity with many residues being conserved among those CVAs that bind ICAM-1.
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(as it appears on PubMed at http://www.pubmed.gov), where 16004874 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16004874}}
==About this Structure==
==About this Structure==
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[[Category: Icam-1,kilifi,cd54,human coxsackievirus a21]]
[[Category: Icam-1,kilifi,cd54,human coxsackievirus a21]]
[[Category: Icosahedral virus]]
[[Category: Icosahedral virus]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:17:28 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 17:56:32 2008''

Revision as of 14:56, 27 July 2008

Image:1z7z.png

Template:STRUCTURE 1z7z

Cryo-em structure of human coxsackievirus A21 complexed with five domain icam-1kilifi

Template:ABSTRACT PUBMED 16004874

About this Structure

1Z7Z is a Protein complex structure of sequences from Homo sapiens and Human coxsackievirus a21. Full crystallographic information is available from OCA.

Reference

The crystal structure of coxsackievirus A21 and its interaction with ICAM-1., Xiao C, Bator-Kelly CM, Rieder E, Chipman PR, Craig A, Kuhn RJ, Wimmer E, Rossmann MG, Structure. 2005 Jul;13(7):1019-33. PMID:16004874

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