1z92

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[[Image:1z92.gif|left|200px]]
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{{STRUCTURE_1z92| PDB=1z92 | SCENE= }}
{{STRUCTURE_1z92| PDB=1z92 | SCENE= }}
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'''structure of interleukin-2 with its alpha receptor'''
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===structure of interleukin-2 with its alpha receptor===
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==Overview==
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Interleukin-2 (IL-2) is an immunoregulatory cytokine that binds sequentially to the alpha (IL-2Ralpha), beta (IL-2Rbeta), and common gamma chain (gammac) receptor subunits. Here we present the 2.8 angstrom crystal structure of a complex between human IL-2 and IL-2Ralpha, which interact in a docking mode distinct from that of other cytokine receptor complexes. IL-2Ralpha is composed of strand-swapped "sushi-like" domains, unlike the classical cytokine receptor fold. As a result of this domain swap, IL-2Ralpha uses a composite surface to dock into a groove on IL-2 that also serves as a binding site for antagonist drugs. With this complex, we now have representative structures for each class of hematopoietic cytokine receptor-docking modules.
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(as it appears on PubMed at http://www.pubmed.gov), where 15933202 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15933202}}
==Disease==
==Disease==
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[[Category: Interleukin-2]]
[[Category: Interleukin-2]]
[[Category: Interleukin-2 alpha receptor]]
[[Category: Interleukin-2 alpha receptor]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:19:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:16:39 2008''

Revision as of 04:16, 28 July 2008

Image:1z92.png

Template:STRUCTURE 1z92

Contents

structure of interleukin-2 with its alpha receptor

Template:ABSTRACT PUBMED 15933202

Disease

Known disease associated with this structure: Severe combined immunodeficiency due to IL2 deficiency OMIM:[147680], Interleukin-2 receptor, alpha chain, deficiency of OMIM:[147730], Diabetes mellitus, insulin-dependent, susceptibility to, 10 OMIM:[147730]

About this Structure

1Z92 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

The structure of interleukin-2 complexed with its alpha receptor., Rickert M, Wang X, Boulanger MJ, Goriatcheva N, Garcia KC, Science. 2005 Jun 3;308(5727):1477-80. PMID:15933202

Page seeded by OCA on Mon Jul 28 07:16:39 2008

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