1z98

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[[Image:1z98.gif|left|200px]]
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{{Seed}}
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[[Image:1z98.png|left|200px]]
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{{STRUCTURE_1z98| PDB=1z98 | SCENE= }}
{{STRUCTURE_1z98| PDB=1z98 | SCENE= }}
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'''Crystal structure of the spinach aquaporin SoPIP2;1 in a closed conformation'''
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===Crystal structure of the spinach aquaporin SoPIP2;1 in a closed conformation===
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==Overview==
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Plants counteract fluctuations in water supply by regulating all aquaporins in the cell plasma membrane. Channel closure results either from the dephosphorylation of two conserved serine residues under conditions of drought stress, or from the protonation of a conserved histidine residue following a drop in cytoplasmic pH due to anoxia during flooding. Here we report the X-ray structure of the spinach plasma membrane aquaporin SoPIP2;1 in its closed conformation at 2.1 A resolution and in its open conformation at 3.9 A resolution, and molecular dynamics simulations of the initial events governing gating. In the closed conformation loop D caps the channel from the cytoplasm and thereby occludes the pore. In the open conformation loop D is displaced up to 16 A and this movement opens a hydrophobic gate blocking the channel entrance from the cytoplasm. These results reveal a molecular gating mechanism which appears conserved throughout all plant plasma membrane aquaporins.
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The line below this paragraph, {{ABSTRACT_PUBMED_16340961}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16340961 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16340961}}
==About this Structure==
==About this Structure==
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[[Category: Integral membrane protein]]
[[Category: Integral membrane protein]]
[[Category: Pip]]
[[Category: Pip]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:20:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:34:07 2008''

Revision as of 15:34, 27 July 2008

Image:1z98.png

Template:STRUCTURE 1z98

Crystal structure of the spinach aquaporin SoPIP2;1 in a closed conformation

Template:ABSTRACT PUBMED 16340961

About this Structure

1Z98 is a Single protein structure of sequence from Spinacia oleracea. Full crystallographic information is available from OCA.

Reference

Structural mechanism of plant aquaporin gating., Tornroth-Horsefield S, Wang Y, Hedfalk K, Johanson U, Karlsson M, Tajkhorshid E, Neutze R, Kjellbom P, Nature. 2006 Feb 9;439(7077):688-94. Epub 2005 Dec 7. PMID:16340961

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