1z9e

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[[Image:1z9e.gif|left|200px]]
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{{STRUCTURE_1z9e| PDB=1z9e | SCENE= }}
{{STRUCTURE_1z9e| PDB=1z9e | SCENE= }}
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'''Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75'''
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===Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75===
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==Overview==
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Lens epithelium-derived growth factor (LEDGF)/p75 is the dominant binding partner of HIV-1 integrase (IN) in human cells. We have determined the NMR structure of the integrase-binding domain (IBD) in LEDGF and identified amino acid residues essential for the interaction. The IBD is a compact right-handed bundle composed of five alpha-helices. Based on folding topology, the IBD is structurally related to a diverse family of alpha-helical proteins that includes eukaryotic translation initiation factor eIF4G and karyopherin-beta. LEDGF residues essential for the interaction with IN were localized to interhelical loop regions of the bundle structure. Interaction-defective IN mutants were previously shown to cripple replication although they retained catalytic function. The initial structure determination of a host cell factor that tightly binds to a retroviral enzyme lays the groundwork for understanding enzyme-host interactions important for viral replication.
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{{ABSTRACT_PUBMED_15895093}}
==About this Structure==
==About this Structure==
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1Z9E is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z9E OCA].
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1Z9E is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1Z9E OCA].
==Reference==
==Reference==
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[[Category: Heat repeat-like]]
[[Category: Heat repeat-like]]
[[Category: Ledgf]]
[[Category: Ledgf]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:20:49 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 21:24:17 2008''

Revision as of 18:24, 28 July 2008

Image:1z9e.png

Template:STRUCTURE 1z9e

Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75

Template:ABSTRACT PUBMED 15895093

About this Structure

1Z9E is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Solution structure of the HIV-1 integrase-binding domain in LEDGF/p75., Cherepanov P, Sun ZY, Rahman S, Maertens G, Wagner G, Engelman A, Nat Struct Mol Biol. 2005 Jun;12(6):526-32. Epub 2005 May 15. PMID:15895093

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