1z9l

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[[Image:1z9l.gif|left|200px]]
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{{STRUCTURE_1z9l| PDB=1z9l | SCENE= }}
{{STRUCTURE_1z9l| PDB=1z9l | SCENE= }}
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'''1.7 Angstrom Crystal Structure of the Rat VAP-A MSP Homology Domain'''
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===1.7 Angstrom Crystal Structure of the Rat VAP-A MSP Homology Domain===
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==Overview==
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The FFAT motif is a targeting signal responsible for localizing a number of proteins to the cytosolic surface of the endoplasmic reticulum (ER) and to the nuclear membrane. FFAT motifs bind to members of the highly conserved VAP protein family, which are tethered to the cytoplasmic face of the ER by a C-terminal transmembrane domain. We have solved crystal structures of the rat VAP-A MSP homology domain alone and in complex with an FFAT motif. The co-crystal structure was used to design a VAP mutant that disrupts rat and yeast VAP-FFAT interactions in vitro. The FFAT binding-defective mutant also blocked function of the VAP homolog Scs2p in yeast. Finally, overexpression of the FFAT binding-defective VAP in COS7 cells dramatically altered ER morphology. Our data establish the structural basis of FFAT-mediated ER targeting and suggest that FFAT-targeted proteins play an important role in determining ER morphology.
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(as it appears on PubMed at http://www.pubmed.gov), where 16004875 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16004875}}
==About this Structure==
==About this Structure==
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[[Category: Cytoplasmic domain]]
[[Category: Cytoplasmic domain]]
[[Category: Vap-a]]
[[Category: Vap-a]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:21:17 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 12:51:42 2008''

Revision as of 09:51, 28 July 2008

Image:1z9l.png

Template:STRUCTURE 1z9l

1.7 Angstrom Crystal Structure of the Rat VAP-A MSP Homology Domain

Template:ABSTRACT PUBMED 16004875

About this Structure

1Z9L is a Single protein structure of sequence from Rattus norvegicus. Full crystallographic information is available from OCA.

Reference

Structural basis of FFAT motif-mediated ER targeting., Kaiser SE, Brickner JH, Reilein AR, Fenn TD, Walter P, Brunger AT, Structure. 2005 Jul;13(7):1035-45. PMID:16004875

Page seeded by OCA on Mon Jul 28 12:51:42 2008

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