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1za3

From Proteopedia

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{{STRUCTURE_1za3| PDB=1za3 | SCENE= }}
{{STRUCTURE_1za3| PDB=1za3 | SCENE= }}
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'''The crystal structure of the YSd1 Fab bound to DR5'''
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===The crystal structure of the YSd1 Fab bound to DR5===
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==Overview==
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Functional antibodies were obtained from a library of antigen-binding sites generated by a binary code restricted to tyrosine and serine. An antibody raised against human vascular endothelial growth factor recognized the antigen with high affinity (K(D)=60 nM) and high specificity in cell-based assays. The crystal structure of another antigen binding fragment in complex with its antigen (human death receptor DR5) revealed the structural basis for this minimalist mode of molecular recognition. Natural antigen-binding sites are enriched for tyrosine and serine, and we show that these amino acid residues are intrinsically well suited for molecular recognition. Furthermore, these results demonstrate that molecular recognition can evolve from even the simplest chemical diversity.
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(as it appears on PubMed at http://www.pubmed.gov), where 15854651 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15854651}}
==Disease==
==Disease==
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[[Category: Phage display]]
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[[Category: Protein engineering]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 18:49:29 2008''

Revision as of 15:49, 28 July 2008

Image:1za3.png

Template:STRUCTURE 1za3

Contents

The crystal structure of the YSd1 Fab bound to DR5

Template:ABSTRACT PUBMED 15854651

Disease

Known disease associated with this structure: Squamous cell carcinoma, head and neck OMIM:[603612]

About this Structure

1ZA3 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Molecular recognition by a binary code., Fellouse FA, Li B, Compaan DM, Peden AA, Hymowitz SG, Sidhu SS, J Mol Biol. 2005 May 20;348(5):1153-62. Epub 2005 Apr 1. PMID:15854651

Page seeded by OCA on Mon Jul 28 18:49:29 2008

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