2bml
From Proteopedia
(New page: 200px<br /> <applet load="2bml" size="450" color="white" frame="true" align="right" spinBox="true" caption="2bml, resolution 2.60Å" /> '''OFLOXACIN-LIKE ANTI...) |
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==About this Structure== | ==About this Structure== | ||
| - | 2BML is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]] with SO4, TRS, P6G, XED and PG4 as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/ ]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.28 3.5.1.28]]. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BML OCA]]. | + | 2BML is a [[http://en.wikipedia.org/wiki/Single_protein Single protein]] structure of sequence from [[http://en.wikipedia.org/wiki/Streptococcus_pneumoniae Streptococcus pneumoniae]] with SO4, TRS, P6G, XED and PG4 as [[http://en.wikipedia.org/wiki/ligands ligands]]. Active as [[http://en.wikipedia.org/wiki/N-acetylmuramoyl-L-alanine_amidase N-acetylmuramoyl-L-alanine amidase]], with EC number [[http://www.brenda-enzymes.info/php/result_flat.php4?ecno=3.5.1.28 3.5.1.28]]. Structure known Active Site: AC1. Full crystallographic information is available from [[http://ispc.weizmann.ac.il/oca-bin/ocashort?id=2BML OCA]]. |
==Reference== | ==Reference== | ||
Ofloxacin-like antibiotics inhibit pneumococcal cell wall-degrading virulence factors., Fernandez-Tornero C, Garcia E, de Pascual-Teresa B, Lopez R, Gimenez-Gallego G, Romero A, J Biol Chem. 2005 May 20;280(20):19948-57. Epub 2005 Mar 15. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15769740 15769740] | Ofloxacin-like antibiotics inhibit pneumococcal cell wall-degrading virulence factors., Fernandez-Tornero C, Garcia E, de Pascual-Teresa B, Lopez R, Gimenez-Gallego G, Romero A, J Biol Chem. 2005 May 20;280(20):19948-57. Epub 2005 Mar 15. PMID:[http://ispc.weizmann.ac.il//pmbin/getpm?pmid=15769740 15769740] | ||
| + | [[Category: N-acetylmuramoyl-L-alanine amidase]] | ||
[[Category: Single protein]] | [[Category: Single protein]] | ||
[[Category: Streptococcus pneumoniae]] | [[Category: Streptococcus pneumoniae]] | ||
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[[Category: ofloxacin-like antibiotics]] | [[Category: ofloxacin-like antibiotics]] | ||
| - | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on | + | ''Page seeded by [http://ispc.weizmann.ac.il/oca OCA ] on Tue Oct 30 12:05:51 2007'' |
Revision as of 10:01, 30 October 2007
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OFLOXACIN-LIKE ANTIBIOTICS INHIBIT PNEUMOCOCCAL CELL WALL DEGRADING VIRULENCE FACTORS
Overview
The search for new drugs against Streptococcus pneumoniae (pneumococcus), is driven by the 1.5 million deaths it causes annually. Choline-binding, proteins attach to the pneumococcal cell wall through domains that, recognize choline moieties, and their involvement in pneumococcal, virulence makes them potential targets for drug development. We have, defined chemical criteria involved in the docking of small molecules from, a three-dimensional structural library to the major pneumococcal autolysin, (LytA) choline binding domain. These criteria were used to identify, compounds that could interfere with the attachment of this protein to the, cell wall, and several quinolones that fit this framework were found to, inhibit the cell wall-degrading activity of LytA. Furthermore, these, compounds ... [(full description)]
About this Structure
2BML is a [Single protein] structure of sequence from [Streptococcus pneumoniae] with SO4, TRS, P6G, XED and PG4 as [ligands]. Active as [N-acetylmuramoyl-L-alanine amidase], with EC number [3.5.1.28]. Structure known Active Site: AC1. Full crystallographic information is available from [OCA].
Reference
Ofloxacin-like antibiotics inhibit pneumococcal cell wall-degrading virulence factors., Fernandez-Tornero C, Garcia E, de Pascual-Teresa B, Lopez R, Gimenez-Gallego G, Romero A, J Biol Chem. 2005 May 20;280(20):19948-57. Epub 2005 Mar 15. PMID:15769740
Page seeded by OCA on Tue Oct 30 12:05:51 2007
Categories: N-acetylmuramoyl-L-alanine amidase | Single protein | Streptococcus pneumoniae | Fernandez-Tornero, C. | Garcia, E. | Gimenez-Gallego, G. | Lopez, R. | Pascual-Teresa, B.D. | Romero, A. | P6G | PG4 | SO4 | TRS | XED | Cell wall attachment | Choline-binding domain | Ofloxacin-like antibiotics
