1zb1

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{{STRUCTURE_1zb1| PDB=1zb1 | SCENE= }}
{{STRUCTURE_1zb1| PDB=1zb1 | SCENE= }}
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'''Structure basis for endosomal targeting by the Bro1 domain'''
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===Structure basis for endosomal targeting by the Bro1 domain===
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==Overview==
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Proteins delivered to the lysosome or the yeast vacuole via late endosomes are sorted by the ESCRT complexes and by associated proteins, including Alix and its yeast homolog Bro1. Alix, Bro1, and several other late endosomal proteins share a conserved 160 residue Bro1 domain whose boundaries, structure, and function have not been characterized. The crystal structure of the Bro1 domain of Bro1 reveals a folded core of 367 residues. The extended Bro1 domain is necessary and sufficient for binding to the ESCRT-III subunit Snf7 and for the recruitment of Bro1 to late endosomes. The structure resembles a boomerang with its concave face filled in and contains a triple tetratricopeptide repeat domain as a substructure. Snf7 binds to a conserved hydrophobic patch on Bro1 that is required for protein complex formation and for the protein-sorting function of Bro1. These results define a conserved mechanism whereby Bro1 domain-containing proteins are targeted to endosomes by Snf7 and its orthologs.
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(as it appears on PubMed at http://www.pubmed.gov), where 15935782 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15935782}}
==About this Structure==
==About this Structure==
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[[Category: Snf7]]
[[Category: Snf7]]
[[Category: Trafficking]]
[[Category: Trafficking]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:27:56 2008''

Revision as of 17:28, 28 July 2008

Image:1zb1.png

Template:STRUCTURE 1zb1

Structure basis for endosomal targeting by the Bro1 domain

Template:ABSTRACT PUBMED 15935782

About this Structure

1ZB1 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Structural basis for endosomal targeting by the Bro1 domain., Kim J, Sitaraman S, Hierro A, Beach BM, Odorizzi G, Hurley JH, Dev Cell. 2005 Jun;8(6):937-47. PMID:15935782

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