1zb7

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{{STRUCTURE_1zb7| PDB=1zb7 | SCENE= }}
{{STRUCTURE_1zb7| PDB=1zb7 | SCENE= }}
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'''Crystal Structure of Botulinum Neurotoxin Type G Light Chain'''
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===Crystal Structure of Botulinum Neurotoxin Type G Light Chain===
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==Overview==
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The seven serotypes (A-G) of botulinum neurotoxins (BoNTs) block neurotransmitter release through their specific proteolysis of one of the three proteins of the soluble N-ethylmaleimide-sensitive-factor attachment protein receptor (SNARE) complex. BoNTs have stringent substrate specificities that are unique for metalloprotease in that they require exceptionally long substrates (1). To understand the molecular reasons for the unique specificities of the BoNTs, we determined the crystal structure of the catalytic light chain (LC) of Clostridium botulinum neurotoxin type G (BoNT/G-LC) at 2.35 A resolution. The structure of BoNT/G-LC reveals a C-terminal beta-sheet that is critical for LC oligomerization and is unlike that seen in the other LC structures. Its structural comparison with thermolysin and the available pool of LC structures reveals important serotype differences that are likely to be involved in substrate recognition of the P1' residue. In addition, structural and sequence analyses have identified a potential exosite of BoNT/G-LC that recognizes a SNARE recognition motif of VAMP.
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(as it appears on PubMed at http://www.pubmed.gov), where 16008342 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16008342}}
==About this Structure==
==About this Structure==
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[[Category: Yu, W.]]
[[Category: Yu, W.]]
[[Category: Hexxh metalloprotease]]
[[Category: Hexxh metalloprotease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:24:41 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:52:09 2008''

Revision as of 01:52, 29 July 2008

Image:1zb7.png

Template:STRUCTURE 1zb7

Crystal Structure of Botulinum Neurotoxin Type G Light Chain

Template:ABSTRACT PUBMED 16008342

About this Structure

1ZB7 is a Single protein structure of sequence from Clostridium botulinum. Full crystallographic information is available from OCA.

Reference

Crystal structure of botulinum neurotoxin type G light chain: serotype divergence in substrate recognition., Arndt JW, Yu W, Bi F, Stevens RC, Biochemistry. 2005 Jul 19;44(28):9574-80. PMID:16008342

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