This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1zbx

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1zbx.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1zbx.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1zbx| PDB=1zbx | SCENE= }}
{{STRUCTURE_1zbx| PDB=1zbx | SCENE= }}
-
'''Crystal structure of a Orc1p-Sir1p complex'''
+
===Crystal structure of a Orc1p-Sir1p complex===
-
==Overview==
+
<!--
-
The interaction between silence information regulator 1 protein (Sir1p) and origin recognition complex 1 protein (Orc1p), the largest subunit of the origin recognition complex, plays an important role in the establishment of transcriptional silencing at the cryptic mating-type gene loci in Saccharomyces cerevisiae. Sir1p binds the N-terminal region of Orc1p encompassing a Bromo-adjacent homology (BAH) domain found in various chromatin-associated proteins. To understand the molecular mechanism of Sir protein recruitment, we have determined a 2.5-A cocrystal structure of the N-terminal domain of Orc1p in complex with the Orc1p-interacting domain of Sir1p. The structure reveals that Sir1p Orc1p-interacting domain has a bilobal structure: an alpha/beta N-terminal lobe and a C-terminal lobe resembling the Tudor domain royal family fold. The N-terminal lobe of Sir1p binds in a shallow groove between a helical subdomain and the BAH domain of Orc1p. The structure provides a mechanistic understanding of Orc1p-Sir1p interaction specificity, as well as insights into protein-protein interactions involving BAH domains in general.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15937111}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15937111 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15937111}}
==About this Structure==
==About this Structure==
Line 29: Line 33:
[[Category: Silencing]]
[[Category: Silencing]]
[[Category: Silent information regulator]]
[[Category: Silent information regulator]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:26:20 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 07:21:35 2008''

Revision as of 04:21, 28 July 2008

Image:1zbx.png

Template:STRUCTURE 1zbx

Crystal structure of a Orc1p-Sir1p complex

Template:ABSTRACT PUBMED 15937111

About this Structure

1ZBX is a Protein complex structure of sequences from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Structural basis for origin recognition complex 1 protein-silence information regulator 1 protein interaction in epigenetic silencing., Hsu HC, Stillman B, Xu RM, Proc Natl Acad Sci U S A. 2005 Jun 14;102(24):8519-24. Epub 2005 Jun 3. PMID:15937111

Page seeded by OCA on Mon Jul 28 07:21:35 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1zbx"
Personal tools