1zc5

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[[Image:1zc5.gif|left|200px]]
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{{Seed}}
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[[Image:1zc5.png|left|200px]]
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{{STRUCTURE_1zc5| PDB=1zc5 | SCENE= }}
{{STRUCTURE_1zc5| PDB=1zc5 | SCENE= }}
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'''Structure of the RNA signal essential for translational frameshifting in HIV-1'''
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===Structure of the RNA signal essential for translational frameshifting in HIV-1===
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==Overview==
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Many pathogenic viruses use a programmed -1 translational frameshifting mechanism to regulate synthesis of their structural and enzymatic proteins. Frameshifting is vital for viral replication. A slippery sequence bound at the ribosomal A and P sites as well as a downstream stimulatory RNA structure are essential for frameshifting. Conflicting data have been reported concerning the structure of the downstream RNA signal in human immunodeficiency virus type 1 (HIV-1). Here, the solution structure of the HIV-1 frameshifting RNA signal was solved by heteronuclear NMR spectroscopy. This structure reveals a long hairpin fold with an internal three-nucleotide bulge. The internal loop introduces a bend between the lower and upper helical regions, a structural feature often seen in frameshifting pseudoknots. The NMR structure correlates with chemical probing data. The upper stem rich in conserved G-C Watson-Crick base-pairs is highly stable, whereas the bulge region and the lower stem are more flexible.
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The line below this paragraph, {{ABSTRACT_PUBMED_15907937}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15907937 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15907937}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZC5 OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZC5 OCA].
==Reference==
==Reference==
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[[Category: Yoshizawa, S.]]
[[Category: Yoshizawa, S.]]
[[Category: Rna bulged helix]]
[[Category: Rna bulged helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:27:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:53:48 2008''

Revision as of 01:53, 29 July 2008

Image:1zc5.png

Template:STRUCTURE 1zc5

Structure of the RNA signal essential for translational frameshifting in HIV-1

Template:ABSTRACT PUBMED 15907937

About this Structure

Full experimental information is available from OCA.

Reference

Structure of the RNA signal essential for translational frameshifting in HIV-1., Gaudin C, Mazauric MH, Traikia M, Guittet E, Yoshizawa S, Fourmy D, J Mol Biol. 2005 Jun 24;349(5):1024-35. PMID:15907937

Page seeded by OCA on Tue Jul 29 04:53:48 2008

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