1zdx

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[[Image:1zdx.gif|left|200px]]
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{{STRUCTURE_1zdx| PDB=1zdx | SCENE= }}
{{STRUCTURE_1zdx| PDB=1zdx | SCENE= }}
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'''Solution Structure of the type 1 pilus assembly platform FimD(25-125)'''
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===Solution Structure of the type 1 pilus assembly platform FimD(25-125)===
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==Overview==
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Adhesive type 1 pili from uropathogenic Escherichia coli are filamentous protein complexes that are attached to the assembly platform FimD in the outer membrane. During pilus assembly, FimD binds complexes between the chaperone FimC and type 1 pilus subunits in the periplasm and mediates subunit translocation to the cell surface. Here we report nuclear magnetic resonance and X-ray protein structures of the N-terminal substrate recognition domain of FimD (FimD(N)) before and after binding of a chaperone-subunit complex. FimD(N) consists of a flexible N-terminal segment of 24 residues, a structured core with a novel fold, and a C-terminal hinge segment. In the ternary complex, residues 1-24 of FimD(N) specifically interact with both FimC and the subunit, acting as a sensor for loaded FimC molecules. Together with in vivo complementation studies, we show how this mechanism enables recognition and discrimination of different chaperone-subunit complexes by bacterial pilus assembly platforms.
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The line below this paragraph, {{ABSTRACT_PUBMED_15920478}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15920478 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15920478}}
==About this Structure==
==About this Structure==
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1ZDX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZDX OCA].
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1ZDX is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Escherichia_coli Escherichia coli]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZDX OCA].
==Reference==
==Reference==
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:30:34 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 00:04:43 2008''

Revision as of 21:04, 27 July 2008

Image:1zdx.png

Template:STRUCTURE 1zdx

Solution Structure of the type 1 pilus assembly platform FimD(25-125)

Template:ABSTRACT PUBMED 15920478

About this Structure

1ZDX is a Single protein structure of sequence from Escherichia coli. Full experimental information is available from OCA.

Reference

Structural basis of chaperone-subunit complex recognition by the type 1 pilus assembly platform FimD., Nishiyama M, Horst R, Eidam O, Herrmann T, Ignatov O, Vetsch M, Bettendorff P, Jelesarov I, Grutter MG, Wuthrich K, Glockshuber R, Capitani G, EMBO J. 2005 Jun 15;24(12):2075-86. Epub 2005 May 26. PMID:15920478

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