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1zh1

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{{STRUCTURE_1zh1| PDB=1zh1 | SCENE= }}
{{STRUCTURE_1zh1| PDB=1zh1 | SCENE= }}
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'''Structure of the zinc-binding domain of HCV NS5A'''
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===Structure of the zinc-binding domain of HCV NS5A===
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==Overview==
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Hepatitis C virus (HCV) is a human pathogen affecting nearly 3% of the world's population. Chronic infections can lead to cirrhosis and liver cancer. The RNA replication machine of HCV is a multi-subunit membrane-associated complex. The non-structural protein NS5A is an active component of HCV replicase, as well as a pivotal regulator of replication and a modulator of cellular processes ranging from innate immunity to dysregulated cell growth. NS5A is a large phosphoprotein (56-58 kDa) with an amphipathic alpha-helix at its amino terminus that promotes membrane association. After this helix region, NS5A is organized into three domains. The N-terminal domain (domain I) coordinates a single zinc atom per protein molecule. Mutations disrupting either the membrane anchor or zinc binding of NS5A are lethal for RNA replication. However, probing the role of NS5A in replication has been hampered by a lack of structural information about this multifunctional protein. Here we report the structure of NS5A domain I at 2.5-A resolution, which contains a novel fold, a new zinc-coordination motif and a disulphide bond. We use molecular surface analysis to suggest the location of protein-, RNA- and membrane-interaction sites.
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(as it appears on PubMed at http://www.pubmed.gov), where 15902263 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15902263}}
==About this Structure==
==About this Structure==
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[[Category: Nonstructural protein 5a]]
[[Category: Nonstructural protein 5a]]
[[Category: Ns5a]]
[[Category: Ns5a]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:36:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:11:11 2008''

Revision as of 05:11, 29 July 2008

Image:1zh1.png

Template:STRUCTURE 1zh1

Structure of the zinc-binding domain of HCV NS5A

Template:ABSTRACT PUBMED 15902263

About this Structure

1ZH1 is a Single protein structure of sequence from Hepatitis c virus. Full crystallographic information is available from OCA.

Reference

Structure of the zinc-binding domain of an essential component of the hepatitis C virus replicase., Tellinghuisen TL, Marcotrigiano J, Rice CM, Nature. 2005 May 19;435(7040):374-9. PMID:15902263

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