1zhh

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{{STRUCTURE_1zhh| PDB=1zhh | SCENE= }}
{{STRUCTURE_1zhh| PDB=1zhh | SCENE= }}
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'''Crystal Structure of the Apo Form of Vibrio Harveyi LUXP Complexed with the Periplasmic Domain of LUXQ'''
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===Crystal Structure of the Apo Form of Vibrio Harveyi LUXP Complexed with the Periplasmic Domain of LUXQ===
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==Overview==
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The extracellular signaling molecule autoinducer-2 (AI-2) mediates quorum-sensing communication in diverse bacterial species. In marine vibrios, binding of AI-2 to the periplasmic receptor LuxP modulates the activity of the inner membrane sensor kinase LuxQ, transducing the AI-2 information into the cytoplasm. Here, we show that Vibrio harveyi LuxP associates with LuxQ in both the presence and absence of AI-2. The 1.9 A X-ray crystal structure of apoLuxP, complexed with the periplasmic domain of LuxQ, reveals that the latter contains two tandem Per/ARNT/Simple-minded (PAS) folds. Thus, although many prokaryotic PAS folds themselves bind ligands, the LuxQ periplasmic PAS folds instead bind LuxP, monitoring its AI-2 occupancy. Mutations that disrupt the apoLuxP:LuxQ interface sensitize V. harveyi to AI-2, implying that AI-2 binding causes the replacement of one set of LuxP:LuxQ contacts with another. These conformational changes switch LuxQ between two opposing enzymatic activities, each of which conveys information to the cytoplasm about the cell density of the surrounding environment.
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(as it appears on PubMed at http://www.pubmed.gov), where 15916958 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15916958}}
==About this Structure==
==About this Structure==
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[[Category: Quorum sensing]]
[[Category: Quorum sensing]]
[[Category: Sensor kinase]]
[[Category: Sensor kinase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:37:42 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 05:24:59 2008''

Revision as of 02:25, 28 July 2008

Image:1zhh.png

Template:STRUCTURE 1zhh

Crystal Structure of the Apo Form of Vibrio Harveyi LUXP Complexed with the Periplasmic Domain of LUXQ

Template:ABSTRACT PUBMED 15916958

About this Structure

1ZHH is a Protein complex structure of sequences from Vibrio harveyi. Full crystallographic information is available from OCA.

Reference

Regulation of LuxPQ receptor activity by the quorum-sensing signal autoinducer-2., Neiditch MB, Federle MJ, Miller ST, Bassler BL, Hughson FM, Mol Cell. 2005 May 27;18(5):507-18. PMID:15916958

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