This old version of Proteopedia is provided for student assignments while the new version is undergoing repairs. Content and edits done in this old version of Proteopedia after March 1, 2026 will eventually be lost when it is retired in about June of 2026.

Apply for new accounts at the new Proteopedia. Your logins will work in both the old and new versions.


1zip

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1zip.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:1zip.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1zip| PDB=1zip | SCENE= }}
{{STRUCTURE_1zip| PDB=1zip | SCENE= }}
-
'''BACILLUS STEAROTHERMOPHILUS ADENYLATE KINASE'''
+
===BACILLUS STEAROTHERMOPHILUS ADENYLATE KINASE===
-
==Overview==
+
<!--
-
Crystal structures of Bacillus stearothermophilus adenylate kinase with bound Ap5A, Mn2+ Ap5A, and Mg2+ Ap5A have been determined by X-ray crystallography to resolutions of 1.6 A, 1.85 A, and 1.96 A, respectively. The protein's lid domain is partially open, being both rotated and translated away from bound Ap5A. The flexibility of the lid domain in the ternary state and its ability to transfer force directly to the the active site is discussed in light of our proposed entropic mechanism for catalytic turnover. The bound Zn2+ atom is demonstrably structural in nature, with no contacts other than its ligating cysteine residues within 5 A. The B. stearothermophilus adenylate kinase lid appears to be a truncated zinc finger domain, lacking the DNA binding finger, which we have termed a zinc knuckle domain. In the Mg2+ Ap5A and Mn2+ Ap5A structures, Mg2+ and Mn2+ demonstrate six coordinate octahedral geometry. The interactions of the Mg2+-coordinated water molecules with the protein and Ap5A phosphate chain demonstrate their involvement in catalyzing phosphate transfer. The protein selects for beta-y (preferred by Mg2+) rather than alpha-gamma (preferred by Mn2+) metal ion coordination by forcing the ATP phosphate chain to have an extended conformation.
+
The line below this paragraph, {{ABSTRACT_PUBMED_9715904}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 9715904 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_9715904}}
==About this Structure==
==About this Structure==
Line 28: Line 32:
[[Category: Kinase]]
[[Category: Kinase]]
[[Category: Phosphotransferase]]
[[Category: Phosphotransferase]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:40:31 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:55:24 2008''

Revision as of 15:55, 27 July 2008

Image:1zip.png

Template:STRUCTURE 1zip

BACILLUS STEAROTHERMOPHILUS ADENYLATE KINASE

Template:ABSTRACT PUBMED 9715904

About this Structure

1ZIP is a Single protein structure of sequence from Geobacillus stearothermophilus. Full crystallographic information is available from OCA.

Reference

Crystal structures of Bacillus stearothermophilus adenylate kinase with bound Ap5A, Mg2+ Ap5A, and Mn2+ Ap5A reveal an intermediate lid position and six coordinate octahedral geometry for bound Mg2+ and Mn2+., Berry MB, Phillips GN Jr, Proteins. 1998 Aug 15;32(3):276-88. PMID:9715904

Page seeded by OCA on Sun Jul 27 18:55:24 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1zip"
Personal tools