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1ziw

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[[Image:1ziw.gif|left|200px]]
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{{Seed}}
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[[Image:1ziw.png|left|200px]]
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{{STRUCTURE_1ziw| PDB=1ziw | SCENE= }}
{{STRUCTURE_1ziw| PDB=1ziw | SCENE= }}
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'''Human Toll-like Receptor 3 extracellular domain structure'''
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===Human Toll-like Receptor 3 extracellular domain structure===
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==Overview==
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Toll-like receptors (TLRs) play key roles in activating immune responses during infection. The human TLR3 ectodomain structure at 2.1 angstroms reveals a large horseshoe-shaped solenoid assembled from 23 leucine-rich repeats (LRRs). Asparagines conserved in the 24-residue LRR motif contribute extensive hydrogen-bonding networks for solenoid stabilization. TLR3 is largely masked by carbohydrate, but one face is glycosylation-free, which suggests its potential role in ligand binding and oligomerization. Highly conserved surface residues and a TLR3-specific LRR insertion form a homodimer interface in the crystal, whereas two patches of positively charged residues and a second insertion would provide an appropriate binding site for double-stranded RNA.
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The line below this paragraph, {{ABSTRACT_PUBMED_15961631}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15961631 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15961631}}
==About this Structure==
==About this Structure==
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[[Category: Wilson, I A.]]
[[Category: Wilson, I A.]]
[[Category: Innate immunity]]
[[Category: Innate immunity]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:40:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:56:30 2008''

Revision as of 17:56, 27 July 2008

Image:1ziw.png

Template:STRUCTURE 1ziw

Human Toll-like Receptor 3 extracellular domain structure

Template:ABSTRACT PUBMED 15961631

About this Structure

1ZIW is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Crystal structure of human toll-like receptor 3 (TLR3) ectodomain., Choe J, Kelker MS, Wilson IA, Science. 2005 Jul 22;309(5734):581-5. Epub 2005 Jun 16. PMID:15961631

Page seeded by OCA on Sun Jul 27 20:56:30 2008

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