1zjm

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[[Image:1zjm.gif|left|200px]]
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{{Seed}}
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[[Image:1zjm.png|left|200px]]
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{{STRUCTURE_1zjm| PDB=1zjm | SCENE= }}
{{STRUCTURE_1zjm| PDB=1zjm | SCENE= }}
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'''Human DNA Polymerase beta complexed with DNA containing an A-A mismatched primer terminus'''
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===Human DNA Polymerase beta complexed with DNA containing an A-A mismatched primer terminus===
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==Overview==
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DNA polymerases occasionally insert the wrong nucleotide. For this error to become a mutation, the mispair must be extended. We report a structure of DNA polymerase beta (pol beta) with a DNA mismatch at the boundary of the polymerase active site. The structure of this complex indicates that the templating adenine of the mispair stacks with the primer terminus adenine while the templating (coding) cytosine is flipped out of the DNA helix. Soaking the crystals of the binary complex with dGTP resulted in crystals of a ternary substrate complex. In this case, the templating cytosine is observed within the DNA helix and forms Watson-Crick hydrogen bonds with the incoming dGTP. The adenine at the primer terminus has rotated into a syn-conformation to interact with the opposite adenine in a planar configuration. Yet, the 3'-hydroxyl on the primer terminus is out of position for efficient nucleotide insertion.
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The line below this paragraph, {{ABSTRACT_PUBMED_16084394}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16084394 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16084394}}
==About this Structure==
==About this Structure==
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[[Category: Dna repair]]
[[Category: Dna repair]]
[[Category: Nucleotidyltransferase]]
[[Category: Nucleotidyltransferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:42:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 09:43:11 2008''

Revision as of 06:43, 29 July 2008

Image:1zjm.png

Template:STRUCTURE 1zjm

Human DNA Polymerase beta complexed with DNA containing an A-A mismatched primer terminus

Template:ABSTRACT PUBMED 16084394

About this Structure

1ZJM is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Nucleotide-induced DNA polymerase active site motions accommodating a mutagenic DNA intermediate., Batra VK, Beard WA, Shock DD, Pedersen LC, Wilson SH, Structure. 2005 Aug;13(8):1225-33. PMID:16084394

Page seeded by OCA on Tue Jul 29 09:43:11 2008

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