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1zl7

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[[Image:1zl7.gif|left|200px]]
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{{STRUCTURE_1zl7| PDB=1zl7 | SCENE= }}
{{STRUCTURE_1zl7| PDB=1zl7 | SCENE= }}
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'''Crystal structure of catalytically-active phospholipase A2 with bound calcium'''
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===Crystal structure of catalytically-active phospholipase A2 with bound calcium===
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==Overview==
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The electrophile Ca(2+) is an essential multifunctional co-factor in the phospholipase A(2) mediated hydrolysis of phospholipids. Crystal structures of an acidic phospholipase A(2) from the venom of Bothrops jararacussu have been determined both in the Ca(2+) free and bound states at 0.97 and 1.60 A resolutions, respectively. In the Ca(2+) bound state, the Ca(2+) ion is penta-coordinated by a distorted pyramidal cage of oxygen and nitrogen atoms that is significantly different to that observed in structures of other Group I/II phospholipases A(2). In the absence of Ca(2+), a water molecule occupies the position of the Ca(2+) ion and the side chain of Asp49 and the calcium-binding loop adopts a different conformation.
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(as it appears on PubMed at http://www.pubmed.gov), where 16376474 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16376474}}
==About this Structure==
==About this Structure==
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==Reference==
==Reference==
Insights into metal ion binding in phospholipases A2: ultra high-resolution crystal structures of an acidic phospholipase A2 in the Ca2+ free and bound states., Murakami MT, Gabdoulkhakov A, Genov N, Cintra AC, Betzel C, Arni RK, Biochimie. 2006 May;88(5):543-9. Epub 2005 Dec 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16376474 16376474]
Insights into metal ion binding in phospholipases A2: ultra high-resolution crystal structures of an acidic phospholipase A2 in the Ca2+ free and bound states., Murakami MT, Gabdoulkhakov A, Genov N, Cintra AC, Betzel C, Arni RK, Biochimie. 2006 May;88(5):543-9. Epub 2005 Dec 5. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/16376474 16376474]
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Crystallization and high-resolution X-ray diffraction data collection of an Asp49 PLA2 from Bothrops jararacussu venom both in the presence and absence of Ca2+ ions., Murakami MT, Michelan-Duarte S, Cintra AC, Arni RK, Biochim Biophys Acta. 2004 Dec 1;1703(1):79-81. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/15588705 15588705]
[[Category: Bothrops jararacussu]]
[[Category: Bothrops jararacussu]]
[[Category: Single protein]]
[[Category: Single protein]]
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[[Category: Asp49-pla2]]
[[Category: Asp49-pla2]]
[[Category: Snake venom]]
[[Category: Snake venom]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:45:42 2008''
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Revision as of 08:58, 29 July 2008

Image:1zl7.png

Template:STRUCTURE 1zl7

Crystal structure of catalytically-active phospholipase A2 with bound calcium

Template:ABSTRACT PUBMED 16376474

About this Structure

1ZL7 is a Single protein structure of sequence from Bothrops jararacussu. Full crystallographic information is available from OCA.

Reference

Insights into metal ion binding in phospholipases A2: ultra high-resolution crystal structures of an acidic phospholipase A2 in the Ca2+ free and bound states., Murakami MT, Gabdoulkhakov A, Genov N, Cintra AC, Betzel C, Arni RK, Biochimie. 2006 May;88(5):543-9. Epub 2005 Dec 5. PMID:16376474

Crystallization and high-resolution X-ray diffraction data collection of an Asp49 PLA2 from Bothrops jararacussu venom both in the presence and absence of Ca2+ ions., Murakami MT, Michelan-Duarte S, Cintra AC, Arni RK, Biochim Biophys Acta. 2004 Dec 1;1703(1):79-81. PMID:15588705

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