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1zla

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[[Image:1zla.gif|left|200px]]
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{{STRUCTURE_1zla| PDB=1zla | SCENE= }}
{{STRUCTURE_1zla| PDB=1zla | SCENE= }}
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'''X-ray Structure of a Kaposi's sarcoma herpesvirus LANA peptide bound to the nucleosomal core'''
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===X-ray Structure of a Kaposi's sarcoma herpesvirus LANA peptide bound to the nucleosomal core===
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==Overview==
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Kaposi's sarcoma-associated herpesvirus (KSHV) latency-associated nuclear antigen (LANA) mediates viral genome attachment to mitotic chromosomes. We find that N-terminal LANA docks onto chromosomes by binding nucleosomes through the folded region of histones H2A-H2B. The same LANA residues were required for both H2A-H2B binding and chromosome association. Further, LANA did not bind Xenopus sperm chromatin, which is deficient in H2A-H2B; chromatin binding was rescued after assembly of nucleosomes containing H2A-H2B. We also describe the 2.9-angstrom crystal structure of a nucleosome complexed with the first 23 LANA amino acids. The LANA peptide forms a hairpin that interacts exclusively with an acidic H2A-H2B region that is implicated in the formation of higher order chromatin structure. Our findings present a paradigm for how nucleosomes may serve as binding platforms for viral and cellular proteins and reveal a previously unknown mechanism for KSHV latency.
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The line below this paragraph, {{ABSTRACT_PUBMED_16469929}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16469929 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16469929}}
==About this Structure==
==About this Structure==
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[[Category: Nucleosome core particle]]
[[Category: Nucleosome core particle]]
[[Category: Protein/protein interaction]]
[[Category: Protein/protein interaction]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:45:48 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:07:59 2008''

Revision as of 12:08, 29 July 2008

Image:1zla.png

Template:STRUCTURE 1zla

X-ray Structure of a Kaposi's sarcoma herpesvirus LANA peptide bound to the nucleosomal core

Template:ABSTRACT PUBMED 16469929

About this Structure

1ZLA is a Protein complex structure of sequences from Homo sapiens, Xenopus laevis and Other sequences. Full crystallographic information is available from OCA.

Reference

The nucleosomal surface as a docking station for Kaposi's sarcoma herpesvirus LANA., Barbera AJ, Chodaparambil JV, Kelley-Clarke B, Joukov V, Walter JC, Luger K, Kaye KM, Science. 2006 Feb 10;311(5762):856-61. PMID:16469929

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