1zll

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[[Image:1zll.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_1zll| PDB=1zll | SCENE= }}
{{STRUCTURE_1zll| PDB=1zll | SCENE= }}
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'''NMR Structure of Unphosphorylated Human Phospholamban Pentamer'''
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===NMR Structure of Unphosphorylated Human Phospholamban Pentamer===
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==Overview==
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Contraction and relaxation of heart muscle cells is regulated by cycling of calcium between cytoplasm and sarcoplasmic reticulum. Human phospholamban (PLN), expressed in the sarcoplasmic reticulum membrane as a 30-kDa homopentamer, controls cellular calcium levels by a mechanism that depends on its phosphorylation. Since PLN was discovered approximately 30 years ago, extensive studies have aimed to explain how it influences calcium pumps and to determine whether it acts as an ion channel. We have determined by solution NMR methods the atomic resolution structure of an unphosphorylated PLN pentamer in dodecylphosphocholine micelles. The unusual bellflower-like assembly is held together by leucine/isoleucine zipper motifs along the membrane-spanning helices. The structure reveals a channel-forming architecture that could allow passage of small ions. The central pore gradually widens toward the cytoplasmic end as the transmembrane helices twist around each other and bend outward. The dynamic N-terminal amphipathic helices point away from the membrane, perhaps facilitating recognition and inhibition of the calcium pump.
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The line below this paragraph, {{ABSTRACT_PUBMED_16043693}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16043693 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16043693}}
==Disease==
==Disease==
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==About this Structure==
==About this Structure==
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1ZLL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZLL OCA].
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1ZLL is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZLL OCA].
==Reference==
==Reference==
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[[Category: Pentamer]]
[[Category: Pentamer]]
[[Category: Super coil]]
[[Category: Super coil]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:46:36 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:02:16 2008''

Revision as of 16:02, 28 July 2008

Image:1zll.png

Template:STRUCTURE 1zll

Contents

NMR Structure of Unphosphorylated Human Phospholamban Pentamer

Template:ABSTRACT PUBMED 16043693

Disease

Known disease associated with this structure: Cardiomyopathy, dilated, 1P OMIM:[172405]

About this Structure

1ZLL is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

The structure of phospholamban pentamer reveals a channel-like architecture in membranes., Oxenoid K, Chou JJ, Proc Natl Acad Sci U S A. 2005 Aug 2;102(31):10870-5. Epub 2005 Jul 25. PMID:16043693

Page seeded by OCA on Mon Jul 28 19:02:16 2008

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