1znf

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[[Image:1znf.gif|left|200px]]
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==Overview==
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{{ABSTRACT_2503871}}
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The three-dimensional solution structure of a zinc finger nucleic acid binding motif has been determined by nuclear magnetic resonance (NMR) spectroscopy. Spectra of a synthetic peptide corresponding to a single zinc finger from the Xenopus protein Xfin yielded distance and dihedral angle constraints that were used to generate structures from distance geometry and restrained molecular dynamics calculations. The zinc finger is an independently folded domain with a compact globular structure in which the zinc atom is bound by two cysteine and two histidine ligands. The polypeptide backbone fold consists of a well-defined helix, starting as alpha and ending as 3(10) helix, packed against two beta strands that are arranged in a hairpin structure. A high density of basic and polar amino acid side chains on the exposed face of the helix are probably involved in DNA binding.
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==About this Structure==
==About this Structure==
1ZNF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. The following page contains interesting information on the relation of 1ZNF with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb87_1.html Zinc Fingers]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZNF OCA].
1ZNF is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Xenopus_laevis Xenopus laevis]. The following page contains interesting information on the relation of 1ZNF with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb87_1.html Zinc Fingers]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZNF OCA].
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==Reference==
 
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Three-dimensional solution structure of a single zinc finger DNA-binding domain., Lee MS, Gippert GP, Soman KV, Case DA, Wright PE, Science. 1989 Aug 11;245(4918):635-7. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/2503871 2503871]
 
[[Category: Single protein]]
[[Category: Single protein]]
[[Category: Xenopus laevis]]
[[Category: Xenopus laevis]]
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[[Category: Wright, P E.]]
[[Category: Wright, P E.]]
[[Category: Zinc finger dna binding domain]]
[[Category: Zinc finger dna binding domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:50:38 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Thu Jun 26 18:10:24 2008''

Revision as of 15:10, 26 June 2008


PDB ID 1znf

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1znf, 37 NMR models ()
Ligands:
Non-Standard Residues: ,


Resources: FirstGlance, OCA, RCSB, PDBsum
Coordinates: save as pdb, mmCIF, xml



THREE-DIMENSIONAL SOLUTION STRUCTURE OF A SINGLE ZINC FINGER DNA-BINDING DOMAIN


Template:ABSTRACT 2503871

About this Structure

1ZNF is a Single protein structure of sequence from Xenopus laevis. The following page contains interesting information on the relation of 1ZNF with [Zinc Fingers]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 18:10:24 2008

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