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1znn

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{{STRUCTURE_1znn| PDB=1znn | SCENE= }}
{{STRUCTURE_1znn| PDB=1znn | SCENE= }}
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'''Structure of the synthase subunit of PLP synthase'''
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===Structure of the synthase subunit of PLP synthase===
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==Overview==
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Pyridoxal 5'-phosphate (PLP, vitamin B6), a cofactor in many enzymatic reactions, has two distinct biosynthetic routes, which do not coexist in any organism. Two proteins, known as PdxS and PdxT, together form a PLP synthase in plants, fungi, archaea, and some eubacteria. PLP synthase is a heteromeric glutamine amidotransferase in which PdxT produces ammonia from glutamine and PdxS combines ammonia with five- and three-carbon phosphosugars to form PLP. In the 2.2-A crystal structure, PdxS is a cylindrical dodecamer of subunits having the classic (beta/alpha)8 barrel fold. PdxS subunits form two hexameric rings with the active sites positioned on the inside. The hexamer and dodecamer forms coexist in solution. A novel phosphate-binding site is suggested by bound sulfate. The sulfate and another bound molecule, methyl pentanediol, were used to model the substrate ribulose 5-phosphate, and to propose catalytic roles for residues in the active site. The distribution of conserved surfaces in the PdxS dodecamer was used to predict a docking site for the glutaminase partner, PdxT.
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{{ABSTRACT_PUBMED_15911615}}
==About this Structure==
==About this Structure==
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[[Category: Zhu, J.]]
[[Category: Zhu, J.]]
[[Category: Tim barrel]]
[[Category: Tim barrel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:51:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 00:19:50 2008''

Revision as of 21:19, 28 July 2008

Image:1znn.png

Template:STRUCTURE 1znn

Structure of the synthase subunit of PLP synthase

Template:ABSTRACT PUBMED 15911615

About this Structure

Full crystallographic information is available from OCA.

Reference

A new arrangement of (beta/alpha)8 barrels in the synthase subunit of PLP synthase., Zhu J, Burgner JW, Harms E, Belitsky BR, Smith JL, J Biol Chem. 2005 Jul 29;280(30):27914-23. Epub 2005 May 23. PMID:15911615

Page seeded by OCA on Tue Jul 29 00:19:50 2008

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