1zp2

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[[Image:1zp2.gif|left|200px]]
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{{Seed}}
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[[Image:1zp2.png|left|200px]]
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{{STRUCTURE_1zp2| PDB=1zp2 | SCENE= }}
{{STRUCTURE_1zp2| PDB=1zp2 | SCENE= }}
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'''Structure of the Mediator subunit cyclin C'''
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===Structure of the Mediator subunit cyclin C===
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==Overview==
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Cyclin C binds the cyclin-dependent kinases CDK8 and CDK3, which regulate mRNA transcription and the cell cycle, respectively. The crystal structure of cyclin C reveals two canonical five-helix repeats and a specific N-terminal helix. In contrast to other cyclins, the N-terminal helix is short, mobile, and in an exposed position that allows for interactions with proteins other than the CDKs. A model of the CDK8/cyclin C pair reveals two regions in the interface with apparently distinct roles. A conserved region explains promiscuous binding of cyclin C to CDK8 and CDK3, and a non-conserved region may be responsible for discrimination of CDK8 against other CDKs involved in transcription. A conserved and cyclin C-specific surface groove may recruit substrates near the CDK8 active site. Activation of CDKs generally involves phosphorylation of a loop at a threonine residue. In CDK8, this loop is longer and the threonine is absent, suggesting an alternative mechanism of activation that we discuss based on a CDK8-cyclin C model.
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The line below this paragraph, {{ABSTRACT_PUBMED_15979093}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 15979093 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15979093}}
==About this Structure==
==About this Structure==
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[[Category: Hoeppner, S.]]
[[Category: Hoeppner, S.]]
[[Category: Cyclin repeat domain]]
[[Category: Cyclin repeat domain]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:53:52 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 19:21:51 2008''

Revision as of 16:22, 28 July 2008

Image:1zp2.png

Template:STRUCTURE 1zp2

Structure of the Mediator subunit cyclin C

Template:ABSTRACT PUBMED 15979093

About this Structure

1ZP2 is a Single protein structure of sequence from Schizosaccharomyces pombe. Full crystallographic information is available from OCA.

Reference

Structure of the mediator subunit cyclin C and its implications for CDK8 function., Hoeppner S, Baumli S, Cramer P, J Mol Biol. 2005 Jul 29;350(5):833-42. PMID:15979093

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