1zp7

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[[Image:1zp7.gif|left|200px]]
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{{STRUCTURE_1zp7| PDB=1zp7 | SCENE= }}
{{STRUCTURE_1zp7| PDB=1zp7 | SCENE= }}
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'''The structure of Bacillus subtilis RecU Holliday junction resolvase and its role in substrate selection and sequence specific cleavage.'''
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===The structure of Bacillus subtilis RecU Holliday junction resolvase and its role in substrate selection and sequence specific cleavage.===
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==Overview==
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We have determined the structure of the enzyme RecU from Bacillus subtilis, that is the general Holliday junction resolving enzyme in Gram-positive bacteria. The enzyme fold reveals a striking similarity to a class of resolvase enzymes found in archaeal sources and members of the type II restriction endonuclease family to which they are related. The structure confirms the presence of active sites formed around clusters of acidic residues that we have also shown to bind divalent cations. Mutagenesis data presented here support the key role of certain residues. The RecU structure suggests a basis for Holliday junction selectivity and suggests how sequence-specific cleavage might be achieved. Models for a resolvase-DNA complex address how the enzyme might organize junctions into an approximately 4-fold symmetric form.
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(as it appears on PubMed at http://www.pubmed.gov), where 16154091 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16154091}}
==About this Structure==
==About this Structure==
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[[Category: Thaw, P.]]
[[Category: Thaw, P.]]
[[Category: Recombination,dna-binding protein,resolvase]]
[[Category: Recombination,dna-binding protein,resolvase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:54:11 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 09:12:28 2008''

Revision as of 06:12, 28 July 2008

Image:1zp7.png

Template:STRUCTURE 1zp7

The structure of Bacillus subtilis RecU Holliday junction resolvase and its role in substrate selection and sequence specific cleavage.

Template:ABSTRACT PUBMED 16154091

About this Structure

1ZP7 is a Single protein structure of sequence from Bacillus subtilis. Full crystallographic information is available from OCA.

Reference

The structure of Bacillus subtilis RecU Holliday junction resolvase and its role in substrate selection and sequence-specific cleavage., McGregor N, Ayora S, Sedelnikova S, Carrasco B, Alonso JC, Thaw P, Rafferty J, Structure. 2005 Sep;13(9):1341-51. PMID:16154091

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