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1zph

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{{STRUCTURE_1zph| PDB=1zph | SCENE= }}
{{STRUCTURE_1zph| PDB=1zph | SCENE= }}
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'''Crystal structure analysis of the minor groove binding quinolinium quaternary salt SN 8315 complexed with CGCGAATTCGCG'''
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===Crystal structure analysis of the minor groove binding quinolinium quaternary salt SN 8315 complexed with CGCGAATTCGCG===
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==Overview==
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The structures of the complexes formed between two anticancer minor-groove-binding quinolinium quaternary salts and the dodecamer d(CGCGAATTCGCG)(2) have been refined to resolutions of 1.6 and 1.8 Angstrom. The complexes crystallized in space group P2(1)2(1)2(1) and the structures are isomorphous with previously solved dodecamer structures. The ligands both bind in the central AT region of the minor groove and although the crystallization conditions and structures of the ligands are very similar, they bind in opposing orientations. The structures are compared with two previously published structures of quinolinium quaternary salts, refined at 2.5 Angstrom resolution, complexed with d(CGCGAATTCGCG)(2) and an e(6)G-modified DNA.
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(as it appears on PubMed at http://www.pubmed.gov), where 16204886 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16204886}}
==About this Structure==
==About this Structure==
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[[Category: Dodecamer]]
[[Category: Dodecamer]]
[[Category: Minor groove binding complex]]
[[Category: Minor groove binding complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 17:54:51 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 14:40:04 2008''

Revision as of 11:40, 29 July 2008

Image:1zph.png

Template:STRUCTURE 1zph

Crystal structure analysis of the minor groove binding quinolinium quaternary salt SN 8315 complexed with CGCGAATTCGCG

Template:ABSTRACT PUBMED 16204886

About this Structure

Full crystallographic information is available from OCA.

Reference

Structures of two minor-groove-binding quinolinium quaternary salts complexed with d(CGCGAATTCGCG)(2) at 1.6 and 1.8 Angstrom resolution., Adams A, Leong C, Denny WA, Guss JM, Acta Crystallogr D Biol Crystallogr. 2005 Oct;61(Pt 10):1348-53. Epub 2005, Sep 28. PMID:16204886

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