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1zt2

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[[Image:1zt2.gif|left|200px]]
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{{STRUCTURE_1zt2| PDB=1zt2 | SCENE= }}
{{STRUCTURE_1zt2| PDB=1zt2 | SCENE= }}
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'''Heterodimeric structure of the core primase.'''
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===Heterodimeric structure of the core primase.===
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==Overview==
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Primases are DNA-dependent RNA polymerases that synthesize the oligoribonucleotide primers essential to DNA replication. In archaeal and eukaryotic organisms, the core primase is a heterodimeric enzyme composed of a small and a large subunit. Here we report a crystallographic and biochemical analysis of the core primase from the archaeon Sulfolobus solfataricus. The structure provides the first three-dimensional description of the large subunit and its interaction with the small subunit. The evolutionary conservation of amino acids at the protein-protein interface implies that the observed mode of subunit association is conserved among archaeal and eukaryotic primases. The orientation of the large subunit in the core primase probably excludes its direct involvement in catalysis. Modeling of a DNA-RNA helix together with structure-based site-directed mutagenesis provides insight into the mechanism of template DNA binding and RNA primer synthesis.
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(as it appears on PubMed at http://www.pubmed.gov), where 16273105 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16273105}}
==About this Structure==
==About this Structure==
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[[Category: Roversi, P.]]
[[Category: Roversi, P.]]
[[Category: Heterodimeric complex]]
[[Category: Heterodimeric complex]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:02:12 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:01:42 2008''

Revision as of 01:01, 29 July 2008

Image:1zt2.png

Template:STRUCTURE 1zt2

Heterodimeric structure of the core primase.

Template:ABSTRACT PUBMED 16273105

About this Structure

1ZT2 is a Protein complex structure of sequences from Sulfolobus solfataricus. Full crystallographic information is available from OCA.

Reference

Structure of the heterodimeric core primase., Lao-Sirieix SH, Nookala RK, Roversi P, Bell SD, Pellegrini L, Nat Struct Mol Biol. 2005 Dec;12(12):1137-44. Epub 2005 Nov 6. PMID:16273105

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