1ztm

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:1ztm.gif|left|200px]]
+
{{Seed}}
 +
[[Image:1ztm.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_1ztm| PDB=1ztm | SCENE= }}
{{STRUCTURE_1ztm| PDB=1ztm | SCENE= }}
-
'''Structure of the Uncleaved Paramyxovirus (hPIV3) Fusion Protein'''
+
===Structure of the Uncleaved Paramyxovirus (hPIV3) Fusion Protein===
-
==Overview==
+
<!--
-
Class I viral fusion proteins share common mechanistic and structural features but little sequence similarity. Structural insights into the protein conformational changes associated with membrane fusion are based largely on studies of the influenza virus hemagglutinin in pre- and postfusion conformations. Here, we present the crystal structure of the secreted, uncleaved ectodomain of the paramyxovirus, human parainfluenza virus 3 fusion (F) protein, a member of the class I viral fusion protein group. The secreted human parainfluenza virus 3 F forms a trimer with distinct head, neck, and stalk regions. Unexpectedly, the structure reveals a six-helix bundle associated with the postfusion form of F, suggesting that the anchor-minus ectodomain adopts a conformation largely similar to the postfusion state. The transmembrane anchor domains of F may therefore profoundly influence the folding energetics that establish and maintain a metastable, prefusion state.
+
The line below this paragraph, {{ABSTRACT_PUBMED_15964978}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 15964978 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_15964978}}
==About this Structure==
==About this Structure==
Line 30: Line 34:
[[Category: Fusion protein]]
[[Category: Fusion protein]]
[[Category: Post-fusion]]
[[Category: Post-fusion]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:03:25 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 15:32:46 2008''

Revision as of 12:32, 29 July 2008

Image:1ztm.png

Template:STRUCTURE 1ztm

Structure of the Uncleaved Paramyxovirus (hPIV3) Fusion Protein

Template:ABSTRACT PUBMED 15964978

About this Structure

1ZTM is a Single protein structure of sequence from Human parainfluenza virus 3. Full crystallographic information is available from OCA.

Reference

Structure of the uncleaved ectodomain of the paramyxovirus (hPIV3) fusion protein., Yin HS, Paterson RG, Wen X, Lamb RA, Jardetzky TS, Proc Natl Acad Sci U S A. 2005 Jun 28;102(26):9288-93. Epub 2005 Jun 17. PMID:15964978

Page seeded by OCA on Tue Jul 29 15:32:46 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/1ztm"
Personal tools