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1ztq

From Proteopedia

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[[Image:1ztq.gif|left|200px]]
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{{Seed}}
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[[Image:1ztq.png|left|200px]]
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{{STRUCTURE_1ztq| PDB=1ztq | SCENE= }}
{{STRUCTURE_1ztq| PDB=1ztq | SCENE= }}
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'''Crystal structure of the catalytic domain of MMP-13 complexed with WAY-033'''
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===Crystal structure of the catalytic domain of MMP-13 complexed with WAY-033===
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==Overview==
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A potent, selective series of MMP-13 inhibitors has been derived from a weak (3.2 microM) inhibitor that did not bear a zinc chelator. Structure-based drug design strategies were employed to append a Zn-chelating group to one end of the molecule and functionality to enhance selectivity to the other. A compound from this series demonstrated rat oral bioavailability and efficacy in a bovine articular cartilage explant model.
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The line below this paragraph, {{ABSTRACT_PUBMED_16005220}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16005220 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16005220}}
==About this Structure==
==About this Structure==
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[[Category: P1' group]]
[[Category: P1' group]]
[[Category: Zinc chelator]]
[[Category: Zinc chelator]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:03:43 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 16:30:10 2008''

Revision as of 13:30, 28 July 2008

Image:1ztq.png

Template:STRUCTURE 1ztq

Crystal structure of the catalytic domain of MMP-13 complexed with WAY-033

Template:ABSTRACT PUBMED 16005220

About this Structure

1ZTQ is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Identification of potent and selective MMP-13 inhibitors., Wu J, Rush TS 3rd, Hotchandani R, Du X, Geck M, Collins E, Xu ZB, Skotnicki J, Levin JI, Lovering FE, Bioorg Med Chem Lett. 2005 Sep 15;15(18):4105-9. PMID:16005220

Page seeded by OCA on Mon Jul 28 16:30:10 2008

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OCA

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