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1zwz

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[[Image:1zwz.gif|left|200px]]
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{{STRUCTURE_1zwz| PDB=1zwz | SCENE= }}
{{STRUCTURE_1zwz| PDB=1zwz | SCENE= }}
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'''Structural comparison of Yeast snoRNP and splicesomal protein snu13p with its homologs'''
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===Structural comparison of Yeast snoRNP and splicesomal protein snu13p with its homologs===
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==Overview==
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Snu13p is a bifunctional yeast protein involved in both messenger RNA splicing as well as ribosomal RNA maturation. Snu13p initiates assembly of ribonucleoprotein particles by interacting with a conserved RNA motif called kink turn. Unlike its archaeal homolog, L7Ae, Snu13p displays differential specificity for functionally distinct kink turns. Thus, the structures of Snu13p at different functional states, including those alone and bound with RNAs, are required to understand how the protein differentially interacts with kink turns. Although the structure of the human homolog of Snu13p bound with a spliceosomal RNA is known, there has not been a report of a structure of free Snu13p. This has hindered our ability to understand the structural basis for Snu13p's substrate specificity. We report a crystal structure of free Snu13p at 1.9A and a detailed structural comparison with its homologs. We show that free Snu13p has nearly an identical conformation as that of its human homolog bound with RNA. Interestingly, both eukaryotic proteins exhibit notable structural differences in their central beta-sheets as compared to their archaeal homolog, L7Ae. The observed structural differences offer a possible explanation to the observed difference in RNA specificity between Snu13p and L7Ae.
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(as it appears on PubMed at http://www.pubmed.gov), where 15963469 is the PubMed ID number.
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{{ABSTRACT_PUBMED_15963469}}
==About this Structure==
==About this Structure==
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[[Category: Protein rna complex]]
[[Category: Protein rna complex]]
[[Category: Rrna modification]]
[[Category: Rrna modification]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:10:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 03:04:55 2008''

Revision as of 00:04, 28 July 2008

Image:1zwz.png

Template:STRUCTURE 1zwz

Structural comparison of Yeast snoRNP and splicesomal protein snu13p with its homologs

Template:ABSTRACT PUBMED 15963469

About this Structure

1ZWZ is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Structural comparison of yeast snoRNP and spliceosomal protein Snu13p with its homologs., Oruganti S, Zhang Y, Li H, Biochem Biophys Res Commun. 2005 Jul 29;333(2):550-4. PMID:15963469

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