1zzp

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[[Image:1zzp.gif|left|200px]]
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{{Seed}}
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[[Image:1zzp.png|left|200px]]
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{{STRUCTURE_1zzp| PDB=1zzp | SCENE= }}
{{STRUCTURE_1zzp| PDB=1zzp | SCENE= }}
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'''Solution structure of the F-actin binding domain of Bcr-Abl/c-Abl'''
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===Solution structure of the F-actin binding domain of Bcr-Abl/c-Abl===
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==Overview==
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The Bcr-Abl tyrosine kinase causes different forms of leukemia in humans. Depending on its position within the cell, Bcr-Abl differentially affects cellular growth. However, no structural and molecular details for the anticipated localization determinants are available. We present the NMR structure of the F-actin binding domain (FABD) of Bcr-Abl and its cellular counterpart c-Abl. The FABD forms a compact left-handed four-helix bundle in solution. We show that the nuclear export signal (NES) previously reported in this region is part of the hydrophobic core and nonfunctional in the intact protein. In contrast, we could identify the critical residues of helix alphaIII that are responsible for F-actin binding and cytoskeletal association. We propose that these interactions represent a major determinant for both Bcr-Abl and c-Abl localization.
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The line below this paragraph, {{ABSTRACT_PUBMED_16109371}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16109371 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16109371}}
==About this Structure==
==About this Structure==
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1ZZP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZZP OCA].
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1ZZP is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Homo_sapiens Homo sapiens]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=1ZZP OCA].
==Reference==
==Reference==
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[[Category: Four helix bundle]]
[[Category: Four helix bundle]]
[[Category: Nuclear export signal]]
[[Category: Nuclear export signal]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:16:50 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 08:25:55 2008''

Revision as of 05:25, 29 July 2008

Image:1zzp.png

Template:STRUCTURE 1zzp

Solution structure of the F-actin binding domain of Bcr-Abl/c-Abl

Template:ABSTRACT PUBMED 16109371

About this Structure

1ZZP is a Single protein structure of sequence from Homo sapiens. Full experimental information is available from OCA.

Reference

Structural basis for the cytoskeletal association of Bcr-Abl/c-Abl., Hantschel O, Wiesner S, Guttler T, Mackereth CD, Rix LL, Mikes Z, Dehne J, Gorlich D, Sattler M, Superti-Furga G, Mol Cell. 2005 Aug 19;19(4):461-73. PMID:16109371

Page seeded by OCA on Tue Jul 29 08:25:55 2008

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