205d

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{{STRUCTURE_205d| PDB=205d | SCENE= }}
{{STRUCTURE_205d| PDB=205d | SCENE= }}
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'''STRUCTURE OF AN RNA DOUBLE HELIX INCLUDING URACIL-URACIL BASE PAIRS IN AN INTERNAL LOOP'''
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===STRUCTURE OF AN RNA DOUBLE HELIX INCLUDING URACIL-URACIL BASE PAIRS IN AN INTERNAL LOOP===
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==Overview==
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The crystal structure of the RNA dodecamer 5'-GGACUUUGGUCC-3' has been determined from X-ray diffraction data to 2.6 A resolution. This oligomer forms an asymmetric double helix in the crystal. Four consecutive non-Watson-Crick base-pairs are formed in the middle of the duplex including the first intrahelical U-U (or T-T) pairs observed in an oligonucleotide crystal structure. Two different conformations of U-U pairs are observed in the context of the surrounding sequence. One of these pairs is highly twisted, allowing a bound water to bridge across strands in the major groove. The crystal packing illustrates a new form of RNA helix-helix interaction.
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(as it appears on PubMed at http://www.pubmed.gov), where 7719854 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7719854}}
==About this Structure==
==About this Structure==
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[[Category: Internal loop]]
[[Category: Internal loop]]
[[Category: Mismatched]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 15:19:57 2008''

Revision as of 12:20, 28 July 2008

Image:205d.png

Template:STRUCTURE 205d

STRUCTURE OF AN RNA DOUBLE HELIX INCLUDING URACIL-URACIL BASE PAIRS IN AN INTERNAL LOOP

Template:ABSTRACT PUBMED 7719854

About this Structure

Full crystallographic information is available from OCA.

Reference

Structure of an RNA double helix including uracil-uracil base pairs in an internal loop., Baeyens KJ, De Bondt HL, Holbrook SR, Nat Struct Biol. 1995 Jan;2(1):56-62. PMID:7719854

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