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241d

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{{STRUCTURE_241d| PDB=241d | SCENE= }}
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'''EXTENSION OF THE FOUR-STRANDED INTERCALATED CYTOSINE MOTIF BY ADENINE.ADENINE BASE PAIRING IN THE CRYSTAL STRUCTURE OF D(CCCAAT)'''
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===EXTENSION OF THE FOUR-STRANDED INTERCALATED CYTOSINE MOTIF BY ADENINE.ADENINE BASE PAIRING IN THE CRYSTAL STRUCTURE OF D(CCCAAT)===
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==Overview==
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The crystal structure of d(CCCAAT), refined at 2.0 A resolution, shows a four stranded molecule in which two parallel duplexes intercalate with opposite polarity, using cytosine.protonated cytosine base pairs. The intercalation motif in this structure is extended by adenine.adenine base pairs. Two topologically distinct broad grooves are found in the lath-like central part of the molecule with the phosphate groups on one side bent over towards each other, stabilized by bridging water molecules. At the 3' ends, two arrangements of intermolecular A.A.T base triplets are found, involving both asymmetric and symmetric A.A base pairs joined to thymine residues by Watson-Crick and reverse Hoogsteen base pairing, respectively.
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(as it appears on PubMed at http://www.pubmed.gov), where 7664099 is the PubMed ID number.
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{{ABSTRACT_PUBMED_7664099}}
==About this Structure==
==About this Structure==
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[[Category: Quadruple helix]]
[[Category: Quadruple helix]]
[[Category: U-dna]]
[[Category: U-dna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:22:08 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 18:27:45 2008''

Revision as of 15:27, 27 July 2008

Image:241d.png

Template:STRUCTURE 241d

EXTENSION OF THE FOUR-STRANDED INTERCALATED CYTOSINE MOTIF BY ADENINE.ADENINE BASE PAIRING IN THE CRYSTAL STRUCTURE OF D(CCCAAT)

Template:ABSTRACT PUBMED 7664099

About this Structure

Full crystallographic information is available from OCA.

Reference

Extension of the four-stranded intercalated cytosine motif by adenine.adenine base pairing in the crystal structure of d(CCCAAT)., Berger I, Kang C, Fredian A, Ratliff R, Moyzis R, Rich A, Nat Struct Biol. 1995 May;2(5):416-25. PMID:7664099

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