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284d

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{{STRUCTURE_284d| PDB=284d | SCENE= }}
{{STRUCTURE_284d| PDB=284d | SCENE= }}
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'''THE BI-LOOP, A NEW GENERAL FOUR-STRANDED DNA MOTIF'''
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===THE BI-LOOP, A NEW GENERAL FOUR-STRANDED DNA MOTIF===
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==Overview==
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The crystal structure of the cyclic octanucleotide d&lt;pATTCATTC&gt; contains two independent molecules that form a novel quadruplex by means of intermolecular Watson-Crick A.T pairs and base stacking. A virtually identical quadruplex composed of G.C pairs was found by earlier x-ray analysis of the linear heptamer d(GCATGCT), when the DNA was looped in the crystal. The close correspondence between these two structures of markedly dissimilar oligonucleotides suggests that they are both examples of a previously unrecognized motif. Their nucleotide sequences have little in common except for two separated 5'-purine-pyrimidine dinucleotides forming the quadruplex, and by implication these so-called "bi-loops" could occur widely in natural DNA. Such structures provide a mechanism for noncovalent linking of polynucleotides in vivo. Their capacity to associate by base stacking, demonstrated in the crystal structure of d(GCATGCT), creates a compact molecular framework made up of four DNA chains within which strand exchange could take place.
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(as it appears on PubMed at http://www.pubmed.gov), where 9159103 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9159103}}
==About this Structure==
==About this Structure==
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[[Category: Cyclic b-dna]]
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[[Category: Quadruple helix]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:25:21 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 20:22:14 2008''

Revision as of 17:22, 27 July 2008

Image:284d.png

Template:STRUCTURE 284d

THE BI-LOOP, A NEW GENERAL FOUR-STRANDED DNA MOTIF

Template:ABSTRACT PUBMED 9159103

About this Structure

Full crystallographic information is available from OCA.

Reference

The bi-loop, a new general four-stranded DNA motif., Salisbury SA, Wilson SE, Powell HR, Kennard O, Lubini P, Sheldrick GM, Escaja N, Alazzouzi E, Grandas A, Pedroso E, Proc Natl Acad Sci U S A. 1997 May 27;94(11):5515-8. PMID:9159103

Page seeded by OCA on Sun Jul 27 20:22:14 2008

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