294d

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{{STRUCTURE_294d| PDB=294d | SCENE= }}
{{STRUCTURE_294d| PDB=294d | SCENE= }}
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'''INTERCALATED CYTOSINE MOTIF AND NOVEL ADENINE CLUSTERS IN THE CRYSTAL STRUCTURE OF TETRAHYMENA TELOMERE'''
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===INTERCALATED CYTOSINE MOTIF AND NOVEL ADENINE CLUSTERS IN THE CRYSTAL STRUCTURE OF TETRAHYMENA TELOMERE===
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==Overview==
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The cytosine-rich strand of the Tetrahymena telomere consists of multiple repeats of sequence d(AACCCC). We have solved the crystal structure of the crystalline repeat sequence at 2.5 A resolution. The adenines form two different and previously unknown clusters (A clusters) in orthogonal directions with their counterparts from other strands, each containing a total of eight adenines. The clusters appear to be stable aggregates held together by base stacking and three different base-pairing modes. Two different types of cytosine tetraplexes are found in the crystal. Each four-stranded complex is composed of two intercalated parallel-stranded duplexes pointing in opposite directions, with hemiprotonated cytosine-cytosine (C.C+) base pairs. The outermost C.C+base pairs are from the 5'-end of each strand in one cytosine tetraplex and from the 3'-end of each strand in the other. The A clusters and the cytosine tetraplexes form two alternating stacking patterns, creating continuous base stacking in two perpendicular directions along the x - and z -axes. The adenine clusters could be organizational motifs for macromolecular RNA.
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{{ABSTRACT_PUBMED_9753739}}
==About this Structure==
==About this Structure==
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[[Category: Quadruple helix]]
[[Category: Quadruple helix]]
[[Category: Unusual dna]]
[[Category: Unusual dna]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:26:02 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:44:24 2008''

Revision as of 11:44, 28 July 2008

Image:294d.png

Template:STRUCTURE 294d

INTERCALATED CYTOSINE MOTIF AND NOVEL ADENINE CLUSTERS IN THE CRYSTAL STRUCTURE OF TETRAHYMENA TELOMERE

Template:ABSTRACT PUBMED 9753739

About this Structure

Full crystallographic information is available from OCA.

Reference

Intercalated cytosine motif and novel adenine clusters in the crystal structure of the Tetrahymena telomere., Cai L, Chen L, Raghavan S, Ratliff R, Moyzis R, Rich A, Nucleic Acids Res. 1998 Oct 15;26(20):4696-705. PMID:9753739

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