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2a02

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[[Image:2a02.gif|left|200px]]
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{{STRUCTURE_2a02| PDB=2a02 | SCENE= }}
{{STRUCTURE_2a02| PDB=2a02 | SCENE= }}
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'''Solution NMR Structure of the Periplasmic Signaling Domain of the Outer Membrane Iron Transporter PupA from Pseudomonas putida.'''
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===Solution NMR Structure of the Periplasmic Signaling Domain of the Outer Membrane Iron Transporter PupA from Pseudomonas putida.===
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==Overview==
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Transcription of the ferric citrate import system is regulated by ferric citrate binding to the outer membrane transporter FecA. A signal indicating transporter occupancy is relayed across the outer membrane to energy-transducing and regulatory proteins embedded in the cytoplasmic membrane. Because transcriptional activation is not coupled to ferric citrate import, an allosteric mechanism underlies this complex signaling mechanism. Using evolution-based statistical analysis we have identified a sparse but structurally connected network of residues that links distant functional sites in FecA. Functional analyses of these positions confirm their involvement in the mechanism that regulates transcriptional activation in response to ferric citrate binding at the cell surface. This mechanism appears to be conserved and provides the structural basis for the allosteric signaling of TonB-dependent transporters.
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(as it appears on PubMed at http://www.pubmed.gov), where 17197416 is the PubMed ID number.
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{{ABSTRACT_PUBMED_17197416}}
==About this Structure==
==About this Structure==
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2A02 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_putida Pseudomonas putida]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A02 OCA].
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2A02 is a [[Single protein]] structure of sequence from [http://en.wikipedia.org/wiki/Pseudomonas_putida Pseudomonas putida]. Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A02 OCA].
==Reference==
==Reference==
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[[Category: Metal transport]]
[[Category: Metal transport]]
[[Category: Protein nmr]]
[[Category: Protein nmr]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:26:32 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 04:49:53 2008''

Revision as of 01:49, 29 July 2008

Image:2a02.png

Template:STRUCTURE 2a02

Solution NMR Structure of the Periplasmic Signaling Domain of the Outer Membrane Iron Transporter PupA from Pseudomonas putida.

Template:ABSTRACT PUBMED 17197416

About this Structure

2A02 is a Single protein structure of sequence from Pseudomonas putida. Full experimental information is available from OCA.

Reference

Signal transduction pathway of TonB-dependent transporters., Ferguson AD, Amezcua CA, Halabi NM, Chelliah Y, Rosen MK, Ranganathan R, Deisenhofer J, Proc Natl Acad Sci U S A. 2007 Jan 9;104(2):513-8. Epub 2006 Dec 29. PMID:17197416

Page seeded by OCA on Tue Jul 29 04:49:53 2008

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