2a26

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{{STRUCTURE_2a26| PDB=2a26 | SCENE= }}
{{STRUCTURE_2a26| PDB=2a26 | SCENE= }}
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'''Crystal structure of the N-terminal, dimerization domain of Siah Interacting Protein'''
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===Crystal structure of the N-terminal, dimerization domain of Siah Interacting Protein===
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==Overview==
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Siah1 is the central component of a multiprotein E3 ubiquitin ligase complex that targets beta-catenin for destruction in response to p53 activation. The E3 complex comprises, in addition to Siah1, Siah-interacting protein (SIP), the adaptor protein Skp1, and the F-box protein Ebi. Here we show that SIP engages Siah1 by means of two elements, both of which are required for mediating beta-catenin destruction in cells. An N-terminal dimerization domain of SIP sits across the saddle-shaped upper surface of Siah1, with two extended legs packing against the sides of Siah1 by means of a consensus PXAXVXP motif that is common to a family of Siah-binding proteins. The C-terminal domain of SIP, which binds to Skp1, protrudes from the lower surface of Siah1, and we propose that this surface provides the scaffold for bringing substrate and the E2 enzyme into apposition in the functional complex.
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The line below this paragraph, {{ABSTRACT_PUBMED_16085652}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 16085652 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16085652}}
==About this Structure==
==About this Structure==
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[[Category: Dimerization]]
[[Category: Dimerization]]
[[Category: Helical hairpin]]
[[Category: Helical hairpin]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:30:27 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 19:27:26 2008''

Revision as of 16:27, 27 July 2008

Image:2a26.png

Template:STRUCTURE 2a26

Crystal structure of the N-terminal, dimerization domain of Siah Interacting Protein

Template:ABSTRACT PUBMED 16085652

About this Structure

2A26 is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structural analysis of Siah1-Siah-interacting protein interactions and insights into the assembly of an E3 ligase multiprotein complex., Santelli E, Leone M, Li C, Fukushima T, Preece NE, Olson AJ, Ely KR, Reed JC, Pellecchia M, Liddington RC, Matsuzawa S, J Biol Chem. 2005 Oct 7;280(40):34278-87. Epub 2005 Aug 4. PMID:16085652

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