2a2x

From Proteopedia

(Difference between revisions)
Jump to: navigation, search
Line 1: Line 1:
-
[[Image:2a2x.jpg|left|200px]]
+
{{Seed}}
 +
[[Image:2a2x.png|left|200px]]
<!--
<!--
Line 9: Line 10:
{{STRUCTURE_2a2x| PDB=2a2x | SCENE= }}
{{STRUCTURE_2a2x| PDB=2a2x | SCENE= }}
-
'''Orally Active Thrombin Inhibitors in Complex with Thrombin Inh12'''
+
===Orally Active Thrombin Inhibitors in Complex with Thrombin Inh12===
-
==Overview==
+
<!--
-
Synthesis and SAR of orally active thrombin inhibitors of the d-Phe-Pro-Arg type with focus on the P2-moiety are described. The unexpected increase in in vitro potency, oral bioavailability, and in vivo activity of inhibitors with dehydroproline as P2-isostere is discussed. Over a period of 24h the antithrombin activity of the most active inhibitors with IC(50)s in the nanomolar range was determined in dogs demonstrating high thrombin inhibitory activity in plasma and an appropriate duration of action after oral administration.
+
The line below this paragraph, {{ABSTRACT_PUBMED_16460939}}, adds the Publication Abstract to the page
 +
(as it appears on PubMed at http://www.pubmed.gov), where 16460939 is the PubMed ID number.
 +
-->
 +
{{ABSTRACT_PUBMED_16460939}}
==About this Structure==
==About this Structure==
Line 31: Line 35:
[[Category: Blood clotting]]
[[Category: Blood clotting]]
[[Category: Serine protease]]
[[Category: Serine protease]]
-
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:32:07 2008''
+
 
 +
''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 14:27:18 2008''

Revision as of 11:27, 28 July 2008

Image:2a2x.png

Template:STRUCTURE 2a2x

Orally Active Thrombin Inhibitors in Complex with Thrombin Inh12

Template:ABSTRACT PUBMED 16460939

About this Structure

2A2X is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Orally active thrombin inhibitors. Part 2: optimization of the P2-moiety., Lange UE, Baucke D, Hornberger W, Mack H, Seitz W, Hoffken HW, Bioorg Med Chem Lett. 2006 May 15;16(10):2648-53. Epub 2006 Feb 3. PMID:16460939

Page seeded by OCA on Mon Jul 28 14:27:18 2008

Proteopedia Page Contributors and Editors (what is this?)

OCA

Retrieved from "http://52.214.119.220/wiki/index.php/2a2x"
Personal tools