2a3d

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==Overview==
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{{ABSTRACT_10318910}}
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Although de novo protein design is an important endeavor with implications for understanding protein folding, until now, structures have been determined for only a few 25- to 30-residue designed miniproteins. Here, the NMR solution structure of a complex 73-residue three-helix bundle protein, alpha3D, is reported. The structure of alpha3D was not based on any natural protein, and yet it shows thermodynamic and spectroscopic properties typical of native proteins. A variety of features contribute to its unique structure, including electrostatics, the packing of a diverse set of hydrophobic side chains, and a loop that incorporates common capping motifs. Thus, it is now possible to design a complex protein with a well defined and predictable three-dimensional structure.
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==About this Structure==
==About this Structure==
The following page contains interesting information on the relation of 2A3D with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb70_1.html Designer Proteins]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A3D OCA].
The following page contains interesting information on the relation of 2A3D with [[http://pdb.rcsb.org/pdb/static.do?p=education_discussion/molecule_of_the_month/pdb70_1.html Designer Proteins]]. Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A3D OCA].
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==Reference==
 
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Solution structure and dynamics of a de novo designed three-helix bundle protein., Walsh ST, Cheng H, Bryson JW, Roder H, DeGrado WF, Proc Natl Acad Sci U S A. 1999 May 11;96(10):5486-91. PMID:[http://www.ncbi.nlm.nih.gov/pubmed/10318910 10318910]
 
[[Category: Designer Proteins]]
[[Category: Designer Proteins]]
[[Category: Bryson, J W.]]
[[Category: Bryson, J W.]]
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[[Category: Walsh, S T.R.]]
[[Category: Walsh, S T.R.]]
[[Category: Three-helix bundle]]
[[Category: Three-helix bundle]]
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Revision as of 15:11, 26 June 2008

Image:2a3d.png

Template:STRUCTURE 2a3d

SOLUTION STRUCTURE OF A DE NOVO DESIGNED SINGLE CHAIN THREE-HELIX BUNDLE (A3D)


Template:ABSTRACT 10318910

About this Structure

The following page contains interesting information on the relation of 2A3D with [Designer Proteins]. Full crystallographic information is available from OCA.

Page seeded by OCA on Thu Jun 26 18:11:02 2008

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