2a4n

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{{STRUCTURE_2a4n| PDB=2a4n | SCENE= }}
{{STRUCTURE_2a4n| PDB=2a4n | SCENE= }}
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'''Crystal structure of aminoglycoside 6'-N-acetyltransferase complexed with coenzyme A'''
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===Crystal structure of aminoglycoside 6'-N-acetyltransferase complexed with coenzyme A===
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==Overview==
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The aminoglycoside-modifying enzyme aminoglycoside 6'-N-acetyltransferase type Ii [AAC(6')-Ii] has been crystallized with its cofactor coenzyme A in space group C222(1), with unit-cell parameters a = 71.5, b = 127.4, c = 76.9 A and one physiologically relevant dimer species per asymmetric unit. The space group previously observed for this complex was P2(1)2(1)2(1), with two dimers per asymmetric unit. By comparing the six available protomer structures of the AAC(6')-Ii-CoA complex, it has been possible to identify regions of plasticity within the protein. Normal-mode analysis of this complex suggests that this plasticity is not an artefact of crystal-packing forces, but that the region of the protomer that displays multiple conformations is intrinsically flexible. It is conjectured that the flexibility is relevant for the cooperative activity observed for the enzyme.
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(as it appears on PubMed at http://www.pubmed.gov), where 16131761 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16131761}}
==About this Structure==
==About this Structure==
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[[Category: Alpha beta protein]]
[[Category: Alpha beta protein]]
[[Category: N-acetyl transferase]]
[[Category: N-acetyl transferase]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:35:53 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 11:14:06 2008''

Revision as of 08:14, 28 July 2008

Image:2a4n.png

Template:STRUCTURE 2a4n

Crystal structure of aminoglycoside 6'-N-acetyltransferase complexed with coenzyme A

Template:ABSTRACT PUBMED 16131761

About this Structure

2A4N is a Single protein structure of sequence from Enterococcus faecium. Full crystallographic information is available from OCA.

Reference

Structures of aminoglycoside acetyltransferase AAC(6')-Ii in a novel crystal form: structural and normal-mode analyses., Burk DL, Xiong B, Breitbach C, Berghuis AM, Acta Crystallogr D Biol Crystallogr. 2005 Sep;61(Pt 9):1273-9. Epub 2005, Aug 16. PMID:16131761

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