2a73

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{{STRUCTURE_2a73| PDB=2a73 | SCENE= }}
{{STRUCTURE_2a73| PDB=2a73 | SCENE= }}
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'''Human Complement Component C3'''
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===Human Complement Component C3===
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==Overview==
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The mammalian complement system is a phylogenetically ancient cascade system that has a major role in innate and adaptive immunity. Activation of component C3 (1,641 residues) is central to the three complement pathways and results in inflammation and elimination of self and non-self targets. Here we present crystal structures of native C3 and its final major proteolytic fragment C3c. The structures reveal thirteen domains, nine of which were unpredicted, and suggest that the proteins of the alpha2-macroglobulin family evolved from a core of eight homologous domains. A double mechanism prevents hydrolysis of the thioester group, essential for covalent attachment of activated C3 to target surfaces. Marked conformational changes in the alpha-chain, including movement of a critical interaction site through a ring formed by the domains of the beta-chain, indicate an unprecedented, conformation-dependent mechanism of activation, regulation and biological function of C3.
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(as it appears on PubMed at http://www.pubmed.gov), where 16177781 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16177781}}
==About this Structure==
==About this Structure==
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[[Category: Roos, A.]]
[[Category: Roos, A.]]
[[Category: Intact thioester]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:41:29 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 04:43:39 2008''

Revision as of 01:43, 28 July 2008

Image:2a73.png

Template:STRUCTURE 2a73

Human Complement Component C3

Template:ABSTRACT PUBMED 16177781

About this Structure

2A73 is a Protein complex structure of sequences from Homo sapiens. Full crystallographic information is available from OCA.

Reference

Structures of complement component C3 provide insights into the function and evolution of immunity., Janssen BJ, Huizinga EG, Raaijmakers HC, Roos A, Daha MR, Nilsson-Ekdahl K, Nilsson B, Gros P, Nature. 2005 Sep 22;437(7058):505-11. PMID:16177781

Page seeded by OCA on Mon Jul 28 04:43:39 2008

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