2a8s

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{{STRUCTURE_2a8s| PDB=2a8s | SCENE= }}
{{STRUCTURE_2a8s| PDB=2a8s | SCENE= }}
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'''2.45 Angstrom Crystal Structure of the Complex Between the Nuclear SnoRNA Decapping Nudix Hydrolase X29, Manganese and GTP'''
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===2.45 Angstrom Crystal Structure of the Complex Between the Nuclear SnoRNA Decapping Nudix Hydrolase X29, Manganese and GTP===
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==Overview==
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X29, a 25 kDa Nudix hydrolase from Xenopus laevis that cleaves 5' caps from U8 snoRNA, crystallizes as a homodimeric apoenzyme. Manganese binds crystals of apo-X29 to form holo-X29 only in the presence of nucleot(s)ide. Structural changes in X29 on nucleo-t(s)ide-assisted Mn(+2) uptake account for the observed cooperativity of metal binding. Structures of X29 with GTP or m7GpppA show a different mode of ligand binding from that of other cap binding proteins and suggest a possible three- or four-metal Nudix reaction mechanism. The X29 dimer has no known RNA binding motif, but its striking surface dipolarity and unique structural features create a plausible RNA binding channel on the positive face of the protein. Because U8 snoRNP is essential for accumulation of mature 5.8S and 28S rRNA in vertebrate ribosome biogenesis, and cap structures are required for U8 stability in vivo, X29 could profoundly influence this fundamental cellular pathway.
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(as it appears on PubMed at http://www.pubmed.gov), where 16472752 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16472752}}
==About this Structure==
==About this Structure==
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[[Category: Wright, H T.]]
[[Category: Wright, H T.]]
[[Category: Modified nudix hydrolase fold]]
[[Category: Modified nudix hydrolase fold]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:45:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:50:16 2008''

Revision as of 17:50, 28 July 2008

Image:2a8s.png

Template:STRUCTURE 2a8s

2.45 Angstrom Crystal Structure of the Complex Between the Nuclear SnoRNA Decapping Nudix Hydrolase X29, Manganese and GTP

Template:ABSTRACT PUBMED 16472752

About this Structure

2A8S is a Single protein structure of sequence from Xenopus laevis. Full crystallographic information is available from OCA.

Reference

Crystal structures of U8 snoRNA decapping nudix hydrolase, X29, and its metal and cap complexes., Scarsdale JN, Peculis BA, Wright HT, Structure. 2006 Feb;14(2):331-43. PMID:16472752

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