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2a9l

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[[Image:2a9l.gif|left|200px]]
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{{Seed}}
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{{STRUCTURE_2a9l| PDB=2a9l | SCENE= }}
{{STRUCTURE_2a9l| PDB=2a9l | SCENE= }}
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'''SOLUTION NMR STRUCTURE OF A SUBSTRATE FOR THE ARCHAEAL PRE-TRNA SPLICING ENDONUCLEASES: THE BULGE-HELIX-BULGE MOTIF, MINIMIZED AVERAGE STRUCTURE'''
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===SOLUTION NMR STRUCTURE OF A SUBSTRATE FOR THE ARCHAEAL PRE-TRNA SPLICING ENDONUCLEASES: THE BULGE-HELIX-BULGE MOTIF, MINIMIZED AVERAGE STRUCTURE===
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==Overview==
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The structure of the bulge-helix-bulge motif that constitutes the intron/exon splice site in H. volcanii pre-tRNATrp has been determined by NMR spectroscopy. The conformations of the two 3 nt bulges, where the pre-tRNA is cleaved, are stabilized by stacking interactions between bulge nucleotides and bases in the adjacent Watson-Crick helices and by a network of backbone hydrogen bonds. Both bulges are presented on the same minor groove face of the central 4 bp helix, and the overall structure has approximate two-fold symmetry, which makes it well-suited for attack by archaeal splicing endonucleases, which are symmetric dimers.
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The line below this paragraph, {{ABSTRACT_PUBMED_9660971}}, adds the Publication Abstract to the page
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(as it appears on PubMed at http://www.pubmed.gov), where 9660971 is the PubMed ID number.
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{{ABSTRACT_PUBMED_9660971}}
==About this Structure==
==About this Structure==
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Full crystallographic information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A9L OCA].
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Full experimental information is available from [http://oca.weizmann.ac.il/oca-bin/ocashort?id=2A9L OCA].
==Reference==
==Reference==
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[[Category: Ribonucleic acid]]
[[Category: Ribonucleic acid]]
[[Category: Rna structure]]
[[Category: Rna structure]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:47:01 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Tue Jul 29 03:24:23 2008''

Revision as of 00:24, 29 July 2008

Image:2a9l.png

Template:STRUCTURE 2a9l

SOLUTION NMR STRUCTURE OF A SUBSTRATE FOR THE ARCHAEAL PRE-TRNA SPLICING ENDONUCLEASES: THE BULGE-HELIX-BULGE MOTIF, MINIMIZED AVERAGE STRUCTURE

Template:ABSTRACT PUBMED 9660971

About this Structure

Full experimental information is available from OCA.

Reference

Solution structure of a substrate for the archaeal pre-tRNA splicing endonucleases: the bulge-helix-bulge motif., Diener JL, Moore PB, Mol Cell. 1998 May;1(6):883-94. PMID:9660971

Page seeded by OCA on Tue Jul 29 03:24:23 2008

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