2ab5

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{{STRUCTURE_2ab5| PDB=2ab5 | SCENE= }}
{{STRUCTURE_2ab5| PDB=2ab5 | SCENE= }}
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'''bI3 LAGLIDADG Maturase'''
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===bI3 LAGLIDADG Maturase===
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==Overview==
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LAGLIDADG endonucleases bind across adjacent major grooves via a saddle-shaped surface and catalyze DNA cleavage. Some LAGLIDADG proteins, called maturases, facilitate splicing by group I introns, raising the issue of how a DNA-binding protein and an RNA have evolved to function together. In this report, crystallographic analysis shows that the global architecture of the bI3 maturase is unchanged from its DNA-binding homologs; in contrast, the endonuclease active site, dispensable for splicing facilitation, is efficiently compromised by a lysine residue replacing essential catalytic groups. Biochemical experiments show that the maturase binds a peripheral RNA domain 50 A from the splicing active site, exemplifying long-distance structural communication in a ribonucleoprotein complex. The bI3 maturase nucleic acid recognition saddle interacts at the RNA minor groove; thus, evolution from DNA to RNA function has been mediated by a switch from major to minor groove interaction.
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(as it appears on PubMed at http://www.pubmed.gov), where 16116439 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16116439}}
==About this Structure==
==About this Structure==
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[[Category: Maturase]]
[[Category: Maturase]]
[[Category: Rna binding]]
[[Category: Rna binding]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 12:36:51 2008''

Revision as of 09:36, 27 July 2008

Image:2ab5.png

Template:STRUCTURE 2ab5

bI3 LAGLIDADG Maturase

Template:ABSTRACT PUBMED 16116439

About this Structure

2AB5 is a Single protein structure of sequence from Saccharomyces cerevisiae. Full crystallographic information is available from OCA.

Reference

Evolution from DNA to RNA recognition by the bI3 LAGLIDADG maturase., Longo A, Leonard CW, Bassi GS, Berndt D, Krahn JM, Hall TM, Weeks KM, Nat Struct Mol Biol. 2005 Sep;12(9):779-87. Epub 2005 Aug 21. PMID:16116439

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