2acf

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{{STRUCTURE_2acf| PDB=2acf | SCENE= }}
{{STRUCTURE_2acf| PDB=2acf | SCENE= }}
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'''Crystal structure of ADRP domain of SARS NSP3'''
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===Crystal structure of ADRP domain of SARS NSP3===
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==Overview==
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The crystal structure of a conserved domain of nonstructural protein 3 (nsP3) from severe acute respiratory syndrome coronavirus (SARS-CoV) has been solved by single-wavelength anomalous dispersion to 1.4 A resolution. The structure of this "X" domain, seen in many single-stranded RNA viruses, reveals a three-layered alpha/beta/alpha core with a macro-H2A-like fold. The putative active site is a solvent-exposed cleft that is conserved in its three structural homologs, yeast Ymx7, Archeoglobus fulgidus AF1521, and Er58 from E. coli. Its sequence is similar to yeast YBR022W (also known as Poa1P), a known phosphatase that acts on ADP-ribose-1''-phosphate (Appr-1''-p). The SARS nsP3 domain readily removes the 1'' phosphate group from Appr-1''-p in in vitro assays, confirming its phosphatase activity. Sequence and structure comparison of all known macro-H2A domains combined with available functional data suggests that proteins of this superfamily form an emerging group of nucleotide phosphatases that dephosphorylate Appr-1''-p.
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(as it appears on PubMed at http://www.pubmed.gov), where 16271890 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16271890}}
==About this Structure==
==About this Structure==
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[[Category: Sars nsp-3]]
[[Category: Sars nsp-3]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:52:26 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 02:28:51 2008''

Revision as of 23:28, 27 July 2008

Image:2acf.png

Template:STRUCTURE 2acf

Crystal structure of ADRP domain of SARS NSP3

Template:ABSTRACT PUBMED 16271890

About this Structure

2ACF is a Single protein structure of sequence from Sars coronavirus. Full crystallographic information is available from OCA.

Reference

Structural basis of severe acute respiratory syndrome coronavirus ADP-ribose-1-phosphate dephosphorylation by a conserved domain of nsP3., Saikatendu KS, Joseph JS, Subramanian V, Clayton T, Griffith M, Moy K, Velasquez J, Neuman BW, Buchmeier MJ, Stevens RC, Kuhn P, Structure. 2005 Nov;13(11):1665-75. PMID:16271890

Page seeded by OCA on Mon Jul 28 02:28:51 2008

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