2adu

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{{STRUCTURE_2adu| PDB=2adu | SCENE= }}
{{STRUCTURE_2adu| PDB=2adu | SCENE= }}
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'''Human Methionine Aminopeptidase Complex with 4-Aryl-1,2,3-triazole Inhibitor'''
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===Human Methionine Aminopeptidase Complex with 4-Aryl-1,2,3-triazole Inhibitor===
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==Overview==
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Inhibitors of human methionine aminopeptidase type 2 (hMetAP2) are of interest as potential treatments for cancer. A new class of small molecule reversible inhibitors of hMetAP2 was discovered and optimized, the 4-aryl-1,2,3-triazoles. Compound 24, a potent inhibitor of cobalt-activated hMetAP2, also inhibits human and mouse endothelial cell growth. Using a mouse matrigel model, this reversible hMetAP2 inhibitor was also shown to inhibit angiogenesis in vivo.
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(as it appears on PubMed at http://www.pubmed.gov), where 16134930 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16134930}}
==About this Structure==
==About this Structure==
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[[Category: Metal binding]]
[[Category: Metal binding]]
[[Category: Protease]]
[[Category: Protease]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:55:15 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sun Jul 27 15:33:33 2008''

Revision as of 12:33, 27 July 2008

Image:2adu.png

Template:STRUCTURE 2adu

Human Methionine Aminopeptidase Complex with 4-Aryl-1,2,3-triazole Inhibitor

Template:ABSTRACT PUBMED 16134930

About this Structure

2ADU is a Single protein structure of sequence from Homo sapiens. Full crystallographic information is available from OCA.

Reference

4-Aryl-1,2,3-triazole: a novel template for a reversible methionine aminopeptidase 2 inhibitor, optimized to inhibit angiogenesis in vivo., Kallander LS, Lu Q, Chen W, Tomaszek T, Yang G, Tew D, Meek TD, Hofmann GA, Schulz-Pritchard CK, Smith WW, Janson CA, Ryan MD, Zhang GF, Johanson KO, Kirkpatrick RB, Ho TF, Fisher PW, Mattern MR, Johnson RK, Hansbury MJ, Winkler JD, Ward KW, Veber DF, Thompson SK, J Med Chem. 2005 Sep 8;48(18):5644-7. PMID:16134930

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