2ae0

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{{STRUCTURE_2ae0| PDB=2ae0 | SCENE= }}
{{STRUCTURE_2ae0| PDB=2ae0 | SCENE= }}
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'''Crystal structure of MltA from Escherichia coli reveals a unique lytic transglycosylase fold'''
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===Crystal structure of MltA from Escherichia coli reveals a unique lytic transglycosylase fold===
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==Overview==
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Lytic transglycosylases are bacterial enzymes involved in the maintenance and growth of the bacterial cell-wall peptidoglycan. They cleave the beta-(1,4)-glycosidic bonds in peptidoglycan forming non-reducing 1,6-anhydromuropeptides. The crystal structure of the lytic transglycosylase MltA from Escherichia coli without a membrane anchor was solved at 2.0A resolution. The enzyme has a fold completely different from those of the other known lytic transglycosylases. It contains two domains, the largest of which has a double-psi beta-barrel fold, similar to that of endoglucanase V from Humicola insolens. The smaller domain also has a beta-barrel fold topology, which is weakly related to that of the RNA-binding domain of ribosomal proteins L25 and TL5. A large groove separates the two domains, which can accommodate a glycan strand, as shown by molecular modelling. Several conserved residues, one of which is in a position equivalent to that of the catalytic acid of the H.insolens endoglucanase, flank this putative substrate-binding groove. Mutation of this residue, Asp308, abolished all activity of the enzyme, supporting the direct participation of this residue in catalysis.
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(as it appears on PubMed at http://www.pubmed.gov), where 16139297 is the PubMed ID number.
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{{ABSTRACT_PUBMED_16139297}}
==About this Structure==
==About this Structure==
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[[Category: Helical sub-domain]]
[[Category: Helical sub-domain]]
[[Category: Small mixed parallel/antiparallel six stranded beta barrel]]
[[Category: Small mixed parallel/antiparallel six stranded beta barrel]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Sat May 3 18:55:39 2008''
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 20:32:03 2008''

Revision as of 17:32, 28 July 2008

Image:2ae0.png

Template:STRUCTURE 2ae0

Crystal structure of MltA from Escherichia coli reveals a unique lytic transglycosylase fold

Template:ABSTRACT PUBMED 16139297

About this Structure

2AE0 is a Single protein structure of sequence from Escherichia coli. Full crystallographic information is available from OCA.

Reference

Crystal structure of MltA from Escherichia coli reveals a unique lytic transglycosylase fold., van Straaten KE, Dijkstra BW, Vollmer W, Thunnissen AM, J Mol Biol. 2005 Oct 7;352(5):1068-80. PMID:16139297

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