2ag8

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{{STRUCTURE_2ag8| PDB=2ag8 | SCENE= }}
{{STRUCTURE_2ag8| PDB=2ag8 | SCENE= }}
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'''NADP complex of Pyrroline-5-carboxylate reductase from Neisseria meningitidis'''
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===NADP complex of Pyrroline-5-carboxylate reductase from Neisseria meningitidis===
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==Overview==
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L-proline is an amino acid that plays an important role in proteins uniquely contributing to protein folding, structure, and stability, and this amino acid serves as a sequence-recognition motif. Proline biosynthesis can occur via two pathways, one from glutamate and the other from arginine. In both pathways, the last step of biosynthesis, the conversion of delta1-pyrroline-5-carboxylate (P5C) to L-proline, is catalyzed by delta1-pyrroline-5-carboxylate reductase (P5CR) using NAD(P)H as a cofactor. We have determined the first crystal structure of P5CR from two human pathogens, Neisseria meningitides and Streptococcus pyogenes, at 2.0 angstroms and 2.15 angstroms resolution, respectively. The catalytic unit of P5CR is a dimer composed of two domains, but the biological unit seems to be species-specific. The N-terminal domain of P5CR is an alpha/beta/alpha sandwich, a Rossmann fold. The C-terminal dimerization domain is rich in alpha-helices and shows domain swapping. Comparison of the native structure of P5CR to structures complexed with L-proline and NADP+ in two quite different primary sequence backgrounds provides unique information about key functional features: the active site and the catalytic mechanism. The inhibitory L-proline has been observed in the crystal structure.
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{{ABSTRACT_PUBMED_16233902}}
==About this Structure==
==About this Structure==
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[[Category: Pyrroline-5-carboxylate reductase]]
[[Category: Pyrroline-5-carboxylate reductase]]
[[Category: Structural genomic]]
[[Category: Structural genomic]]
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''Page seeded by [http://oca.weizmann.ac.il/oca OCA ] on Mon Jul 28 17:49:51 2008''

Revision as of 14:49, 28 July 2008

Image:2ag8.png

Template:STRUCTURE 2ag8

NADP complex of Pyrroline-5-carboxylate reductase from Neisseria meningitidis

Template:ABSTRACT PUBMED 16233902

About this Structure

2AG8 is a Single protein structure of sequence from Neisseria meningitidis. Full crystallographic information is available from OCA.

Reference

Crystal structures of delta1-pyrroline-5-carboxylate reductase from human pathogens Neisseria meningitides and Streptococcus pyogenes., Nocek B, Chang C, Li H, Lezondra L, Holzle D, Collart F, Joachimiak A, J Mol Biol. 2005 Nov 18;354(1):91-106. Epub 2005 Sep 2. PMID:16233902

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